Rabbit MLC1 Polyclonal Antibody | anti-MLC1 antibody

Anti-MLC1 Antibody

Cat. Num. AAA125678

• Gene Names: MLC1; VL; LVM; MLC
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Flow Cytometry, Functional Assay, Western Blot
• Purity: Immunogen affinity purified.
• Synonyms: MLC1, Antibody; Anti-MLC1 Antibody; Membrane protein MLC1; MLC1; KIAA0027; WKL1; modulator of VRAC current 1; anti-MLC1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Rabbit IgG polyclonal antibody for MLC1 detection.
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized. Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

• Applicable Applications for anti-MLC1 antibody: ELISA (Direct ELISA), FCM/FACS (Flow Cytometry), WB (Western Blot)
• Immunogen: E Coli-derived human MLC1 recombinant protein (Position: M1-Q377).
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Relevant Detection Systems: Lab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (please inquire) for Western blot.
• Preparation and Storage: Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Related Product Information for anti-MLC1 antibody

The function of this gene product is unknown; however, homology to other proteins suggests that it may be an integral membrane transporter. Mutations in this gene have been associated with megalencephalic leukoencephalopathy with subcortical cysts, an autosomal recessive neurological disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.

References

1. Duarri, A., Teijido, O., Lopez-Hernandez, T., Scheper, G. C., Barriere, H., Boor, I., Aguado, F., Zorzano, A., Palacin, M., Martinez, A., Lukacs, G. L., van der Knaap, M. S., Nunes, V., Estevez, R. Molecular pathogenesis of megalencephalic leukoencephalopathy with subcortical cysts: mutations in MLC1 cause folding defects. Hum. Molec. Genet. 17: 3728-3739, 2008.
2. Ilja Boor, P. K., de Groot, K., Mejaski-Bosnjak, V., Brenner, C., van der Knaap, M. S., Scheper, G. C., Pronk, J. C. Megalencephalic leukoencephalopathy with subcortical cysts: an update and extended mutation analysis of MLC1. Hum. Mutat. 27: 505-512, 2006.
3. Leegwater, P. A. J., Boor, P. K. I., Yuan, B. Q., van der Steen, J., Visser, A., Konst, A. A. M., Oudejans, C. B. M., Schutgens, R. B. H., Pronk, J. C., van der Knaap, M. S. Identification of novel mutations in MLC1 responsible for megalencephalic leukoencephalopathy with subcortical cysts. Hum. Genet. 110: 279-283, 2002. Note: Erratum: Hum. Genet. 111: 114 only, 2002.

NCBI and Uniprot Product Information

• NCBI GI #: 14589896
• NCBI GeneID: 23209
• NCBI Accession #: NP_055981.1
• NCBI GenBank Nucleotide #: NM_015166.3
• UniProt Accession #: Q15049; Q5JZ83; Q8TAG4; Q96RP5; Q9UGY8; B3KW61; B7Z659
• NCBI Official Full Name: membrane protein MLC1
• NCBI Official Synonym Full Names: megalencephalic leukoencephalopathy with subcortical cysts 1
• NCBI Official Symbol: MLC1
• NCBI Official Synonym Symbols: VL; LVM; MLC
• NCBI Protein Information: membrane protein MLC1
• UniProt Protein Name: Membrane protein MLC1
• UniProt Gene Name: MLC1
• UniProt Synonym Gene Names: KIAA0027; WKL1
• UniProt Entry Name: MLC1_HUMAN