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IHC (Immunohistochemistry)
(MLXIPL Antibody (C-term) (Cat. #AAA287205)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MLXIPL Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit anti-Human, Mouse MLXIPL Polyclonal Antibody | anti-MLXIPL antibody
MLXIPL Antibody (C-term)
Gene Names
MLXIPL; MIO; CHREBP; MONDOB; WBSCR14; WS-bHLH; bHLHd14
Reactivity
Human, Mouse
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
MLXIPL, Antibody; MLXIPL Antibody (C-term); Carbohydrate-responsive element-binding protein; ChREBP; Class D basic helix-loop-helix protein 14; bHLHd14; MLX interactor; MLX-interacting protein-like; WS basic-helix-loop-helix leucine zipper protein; WS-bHLH; Williams-Beuren syndrome chromosomal region 14 protein; MLXIPL; BHLHD14; MIO; WBSCR14; anti-MLXIPL antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This MLXIPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 624-653 amino acids from the C-terminal region of human MLXIPL.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.32 (varies by lot)
Sequence Positions
624-653
Sequence Length
722
Applicable Applications for anti-MLXIPL antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Function
Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity).
Cellular Location
Nucleus.
Tissue Location
Expressed in liver, heart, kidney, cerebellum and intestinal tissues
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohistochemistry)
(MLXIPL Antibody (C-term) (Cat. #AAA287205)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MLXIPL Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohistochemistry)
(MLXIPL Antibody (C-term) (Cat. #AAA287205)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MLXIPL Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(MLXIPL Antibody (C-term) (Cat. #AAA287205) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the MLXIPL antibody detected the MLXIPL protein (arrow).)
WB (Western Blot)
(MLXIPL Antibody (C-term) (Cat. #AAA287205) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the MLXIPL antibody detected the MLXIPL protein (arrow).)
WB (Western Blot)
(All lanes : Anti-MLXIPL Antibody (C-term) at 1:2000 dilutionLane 1: K562 whole cell lysateLane 2: NCI-H1299 whole cell lysateLane 3: Neuro-2a whole cell lysateLane 4: SW620 whole cell lysate Lysates/proteins at 20 ?g per lane.Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 93 kDa Blocking/Dilution buffer: 5% NFDM/TBST.)
WB (Western Blot)
(All lanes : Anti-MLXIPL Antibody (C-term) at 1:2000 dilutionLane 1: K562 whole cell lysateLane 2: NCI-H1299 whole cell lysateLane 3: Neuro-2a whole cell lysateLane 4: SW620 whole cell lysate Lysates/proteins at 20 ?g per lane.Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 93 kDa Blocking/Dilution buffer: 5% NFDM/TBST.)
WB (Western Blot)
(All lanes : Anti-MLXIPL Antibody (C-term) at 1:2000 dilutionLane 1: Neuro-2a whole cell lysateLane 2: SW620 whole cell lysate Lysates/proteins at 20 ?g per lane.Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 93 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
WB (Western Blot)
(All lanes : Anti-MLXIPL Antibody (C-term) at 1:2000 dilutionLane 1: Neuro-2a whole cell lysateLane 2: SW620 whole cell lysate Lysates/proteins at 20 ?g per lane.Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 93 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Related Product Information for anti-MLXIPL antibody
This gene encodes a basic helix-loop-helix leucine zipper
transcription factor of the Myc/Max/Mad superfamily. This protein
forms a heterodimeric complex and binds and activates, in a
glucose-dependent manner, carbohydrate response element (ChoRE)
motifs in the promoters of triglyceride synthesis genes. The gene
is deleted in Williams-Beuren syndrome, a multisystem developmental
disorder caused by the deletion of contiguous genes at chromosome
7q11.23.
transcription factor of the Myc/Max/Mad superfamily. This protein
forms a heterodimeric complex and binds and activates, in a
glucose-dependent manner, carbohydrate response element (ChoRE)
motifs in the promoters of triglyceride synthesis genes. The gene
is deleted in Williams-Beuren syndrome, a multisystem developmental
disorder caused by the deletion of contiguous genes at chromosome
7q11.23.
Product Categories/Family for anti-MLXIPL antibody
References
Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)
Johansen, C.T., et al. Nat. Genet. 42(8):684-687(2010)
Keebler, M.E., et al. Circ Cardiovasc Genet 3(4):358-364(2010)
Chidambaram, M., et al. Metab. Clin. Exp. (2010) In press :
Reynolds, C.A., et al. Hum. Mol. Genet. 19(10):2068-2078(2010)
Johansen, C.T., et al. Nat. Genet. 42(8):684-687(2010)
Keebler, M.E., et al. Circ Cardiovasc Genet 3(4):358-364(2010)
Chidambaram, M., et al. Metab. Clin. Exp. (2010) In press :
Reynolds, C.A., et al. Hum. Mol. Genet. 19(10):2068-2078(2010)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
93073
NCBI Official Full Name
carbohydrate-responsive element-binding protein isoform alpha
NCBI Official Synonym Full Names
MLX interacting protein-like
NCBI Official Symbol
MLXIPL
NCBI Official Synonym Symbols
MIO; CHREBP; MONDOB; WBSCR14; WS-bHLH; bHLHd14
NCBI Protein Information
carbohydrate-responsive element-binding protein
UniProt Protein Name
Carbohydrate-responsive element-binding protein
UniProt Gene Name
MLXIPL
UniProt Synonym Gene Names
BHLHD14; MIO; WBSCR14; ChREBP; bHLHd14; WS-bHLH
UniProt Entry Name
MLXPL_HUMAN
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Product Notes
The MLXIPL mlxipl (Catalog #AAA287205) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 624-653. The MLXIPL Antibody (C-term) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's MLXIPL can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the MLXIPL mlxipl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MLXIPL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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