WB (Western Blot)
(MRTO4 Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the MRTO4 antibody detected the MRTO4 protein (arrow).)
Rabbit MRTO4 Polyclonal Antibody | anti-MRTO4 antibody
MRTO4 Antibody (N-term)
Gene Names
MRTO4; MRT4; C1orf33; dJ657E11.4
Reactivity
HumanPredicted Reactivity: Bovine, Mouse
Applications
ELISA, Western Blot
Synonyms
MRTO4, Antibody; MRTO4 Antibody (N-term); mRNA turnover protein 4 homolog; MRTO4; C1orf33; MRT4; anti-MRTO4 antibody
Host
Rabbit
Reactivity
Human
Predicted Reactivity: Bovine, Mouse
Predicted Reactivity: Bovine, Mouse
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This MRTO4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of human MRTO4.
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Sequence Positions
46-72
Sequence Length
239
Applicable Applications for anti-MRTO4 antibody
ELISA, WB (Western Blot)
Antigen Region
46-72
Function
Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
Cellular Location
Nucleus, nucleolus. Cytoplasm Note=Shuttles between the nucleus and the cytoplasm
Preparation and Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(MRTO4 Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the MRTO4 antibody detected the MRTO4 protein (arrow).)
WB (Western Blot)
(MRTO4 Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the MRTO4 antibody detected the MRTO4 protein (arrow).)
Related Product Information for anti-MRTO4 antibody
CDC25A is a dual specificity (tyr/thr) phosphatase and a putative upregulated c-Myc target gene. It is a regulator of the cell cycle required for progression from G1 to S phase. CDC25A is a member of the CDC25 family of phosphatases. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. Overexpression of CDC25A bypassed the mechanism of cell cycle arrest, leading to enhanced DNA damage and decreased cell survival. Specific degradation of CDC25A is identified as part of the DNA damage checkpoint mechanism and suggested how CDC25A overexpression in human cancers might contribute to tumorigenesis.
References
Michalec, B., et al. Int. J. Biochem. Cell Biol. 42(5):736-748(2010)
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Scherl, A., et al. Mol. Biol. Cell 13(11):4100-4109(2002)
Andersen, J.S., et al. Curr. Biol. 12(1):1-11(2002)
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Scherl, A., et al. Mol. Biol. Cell 13(11):4100-4109(2002)
Andersen, J.S., et al. Curr. Biol. 12(1):1-11(2002)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
mRNA turnover protein 4 homolog
NCBI Official Synonym Full Names
MRTO4 ribosome maturation factor
NCBI Official Symbol
MRTO4
NCBI Official Synonym Symbols
MRT4; C1orf33; dJ657E11.4
NCBI Protein Information
mRNA turnover protein 4 homolog
UniProt Protein Name
mRNA turnover protein 4 homolog
UniProt Gene Name
MRTO4
UniProt Synonym Gene Names
C1orf33; MRT4
UniProt Entry Name
MRT4_HUMAN
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Product Notes
The MRTO4 mrto4 (Catalog #AAA285544) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 46-72. The MRTO4 Antibody (N-term) reacts with Human Predicted Reactivity: Bovine, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's MRTO4 can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the MRTO4 mrto4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MRTO4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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