Rabbit anti-Human, Mouse NAA50 Polyclonal Antibody | anti-NAA50 antibody
NAA50 Rabbit pAb
Gene Names
NAA50; SAN; MAK3; NAT5; NAT13; NAT5P; NAT13P; hNaa50p
Reactivity
Human, Mouse
Applications
Western Blot
Purity
Affinity Purified
Synonyms
NAA50, Antibody; NAA50 Rabbit pAb; SAN; MAK3; NAT5; NAT13; NAT5P; NAT13P; hNaa50p; anti-NAA50 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
This antibody detects endogenous levels of NAT13 at Human, Mouse
Purity/Purification
Affinity Purified
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Sequence Length
169
Applicable Applications for anti-NAA50 antibody
WB (Western Blot)
Immunogen
Synthesized peptide derived from human NAT13
Organism
Human, Mouse
Cellular Localization
Cytoplasm. Nucleus. Localizes to the cytoplasm in interphase cells (PubMed: 17502424)
Function
N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine . Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position . Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins . Autoacetylates in vivo . The relevance of N-epsilon acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo . Component of N-alpha-acetyltransferase complexes containing NAA10 and NAA15, which has N-alpha-acetyltransferase activity. Does not influence the acetyltransferase activity of NAA10 . However, it negatively regulates the N alpha-acetyltransferase activity of the N-terminal acetyltransferase A complex (also called the NatA complex) . The multiprotein complexes probably constitute the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides . Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin:may act by counteracting the function of NAA10.
Preparation and Storage
Store at -15 degree C to -25 degree C / 1 year (Do not lower than -25 degree C)
Related Product Information for anti-NAA50 antibody
N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (PubMed:19744929, PubMed:22311970, PubMed:21900231, PubMed:27484799). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position (PubMed:27484799). Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins (PubMed:19744929). Autoacetylates in vivo (PubMed:19744929). The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo (PubMed:19744929). Component of a N-alpha-acetyltransferase complex containing NAA10 and NAA15, but NAA50 does not influence the acetyltransferase activity of NAA10: this multiprotein complex probably constitutes the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides (PubMed:16507339, PubMed:27484799). Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10 (PubMed:17502424, PubMed:27422821).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
19kD
NCBI Official Full Name
N-alpha-acetyltransferase 50 isoform 1
NCBI Official Synonym Full Names
N(alpha)-acetyltransferase 50, NatE catalytic subunit
NCBI Official Symbol
NAA50
NCBI Official Synonym Symbols
SAN; MAK3; NAT5; NAT13; NAT5P; NAT13P; hNaa50p
NCBI Protein Information
N-alpha-acetyltransferase 50
UniProt Protein Name
N-alpha-acetyltransferase 50
UniProt Gene Name
NAA50
UniProt Synonym Gene Names
MAK3; NAT13; NAT5; hNAT5; hSAN
UniProt Entry Name
NAA50_HUMAN
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Product Notes
The NAA50 naa50 (Catalog #AAA268625) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NAA50 Rabbit pAb reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's NAA50 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot). Researchers should empirically determine the suitability of the NAA50 naa50 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NAA50, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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