WB (Western Blot)
(Figure 1. Western blot analysis of NPR1 using anti-NPR1 antibody.)
Rabbit anti-Human Natriuretic Peptide Receptor A/GC-A/NPR1 Polyclonal Antibody | anti-NPR1 antibody
Anti-Natriuretic Peptide Receptor A/GC-A/NPR1 Antibody
Gene Names
NPR1; ANPa; NPRA; ANPRA; GUC2A; GUCY2A
Reactivity
Human
Applications
ELISA, Immunofluorescence, Immunocytochemistry, Western Blot
Purity
Immunogen affinity purified.
Synonyms
Natriuretic Peptide Receptor A/GC-A/NPR1, Antibody; Anti-Natriuretic Peptide Receptor A/GC-A/NPR1 Antibody; Atrial natriuretic peptide receptor 1; Atrial natriuretic peptide receptor type A; ANP-A; ANPR-A; NPR-A; Guanylate cyclase A; GC-A; NPR1; ANPRA; anti-NPR1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
No cross reactivity with other proteins.
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Sequence Length
1061
Applicable Applications for anti-NPR1 antibody
ELISA (Direct ELISA), IF (Immunofluorescence), ICC (Immunocytochemistry), WB (Western Blot)
Immunogen
E Coli-derived human Natriuretic Peptide Receptor A/GC-A/NPR1 recombinant protein (Position: A58-K501).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.
WB (Western Blot)
(Figure 1. Western blot analysis of NPR1 using anti-NPR1 antibody.)
WB (Western Blot)
(Figure 1. Western blot analysis of NPR1 using anti-NPR1 antibody.)
IF (Immunofluorescence)
IF (Immunofluorescence)
Related Product Information for anti-NPR1 antibody
Description: Rabbit IgG polyclonal antibody for Natriuretic Peptide Receptor A/GC-A/NPR1 detection. Tested with WB, ICC/IF, Direct ELISA in Human.
Background: Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene. It is mapped to 1q21.3. Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms. The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B. Also see NPR3, which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides and BNP.
Background: Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene. It is mapped to 1q21.3. Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms. The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B. Also see NPR3, which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides and BNP.
References
1. Ferrari, P., Weidmann, P., Ferrier, C., Dietler, R., Hollmann, R., Piso, R. J., Wey, J., Shaw, S. Dysregulation of atrial natriuretic factor in hypertension-prone man. J. Clin. Endocr. Metab. 71: 944-951, 1990.
2. Garbers, D. L., Lowe, D. G. Guanylyl cyclase receptors. J. Biol. Chem. 269: 30741-30744, 1994.
3. Kishimoto, I., Rossi, K., Garbers, D. L. A genetic model provides evidence that the receptor for atrial natriuretic peptide (guanylyl cyclase-A) inhibits cardiac ventricular myocyte hypertrophy. Proc. Nat. Acad. Sci. 98: 2703-2706, 2001.
2. Garbers, D. L., Lowe, D. G. Guanylyl cyclase receptors. J. Biol. Chem. 269: 30741-30744, 1994.
3. Kishimoto, I., Rossi, K., Garbers, D. L. A genetic model provides evidence that the receptor for atrial natriuretic peptide (guanylyl cyclase-A) inhibits cardiac ventricular myocyte hypertrophy. Proc. Nat. Acad. Sci. 98: 2703-2706, 2001.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
atrial natriuretic peptide receptor 1
NCBI Official Synonym Full Names
natriuretic peptide receptor 1
NCBI Official Symbol
NPR1
NCBI Official Synonym Symbols
ANPa; NPRA; ANPRA; GUC2A; GUCY2A
NCBI Protein Information
atrial natriuretic peptide receptor 1
UniProt Protein Name
Atrial natriuretic peptide receptor 1
UniProt Gene Name
NPR1
UniProt Synonym Gene Names
ANPRA; ANP-A; ANPR-A; NPR-A; GC-A
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Product Notes
The NPR1 npr1 (Catalog #AAA125413) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Natriuretic Peptide Receptor A/GC-A/NPR1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Natriuretic Peptide Receptor A/GC-A/NPR1 can be used in a range of immunoassay formats including, but not limited to, ELISA (Direct ELISA), IF (Immunofluorescence), ICC (Immunocytochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the NPR1 npr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Natriuretic Peptide Receptor A/GC-A/NPR1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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