Rabbit anti-Human NCAN Polyclonal Antibody | anti-NCAN antibody

Anti-NCAN Antibody, Rabbit Polyclonal

Cat. Num. AAA256714

• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: NCAN, Antibody; Anti-NCAN Antibody, Rabbit Polyclonal; NCAN Antibody, Rabbit PAb, Antigen Affinity Purified; Anti-CSPG3 Antibody; anti-NCAN antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human NCAN
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; PBS, pH7.0 with 0.03% Proclin300

• Applicable Applications for anti-NCAN antibody: IHC (Immunohistochemistry)
• Immunogen: E Coli-derived Human NCAN fragment
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with E Coli-derived Human NCAN fragment, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.

IHC (Immunohiostchemistry)

(Immunochemical staining of human NCAN in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)

IHC (Immunohistochemistry)

(Immunochemical staining of human NCAN in human brain with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-NCAN antibody

Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration. NCAN encodes neurocan, a brain-specific chondroitin sulfate proteoglycan that influences neuronal adhesion and migration. Human neurocan shares 63% sequence identity with both mouse and rat neurocan proteins. Like other known proteoglycans, its N terminus contains an immunoglobulin domain and a series of hyaluronic acid-binding tandem repeats, and its C terminus contains an EGF-like domain, a lectin-like domain, and a complement regulatory-like domain. NCAN is one of the major inhibitory molecules for axon regeneration in nervous injury. NCAN, which stimulates neuroblastoma cells to promote malignant phenotypes, is an extracellular molecule providing a growth advantage to cancer cells.

References

Wang L, et al. (2018) Further evidence of an association between ncan rs1064395 and bipolar disorder. Mol Neuropsychiatry 4 (1): 30-34.Raum H, et al. (2015) A genome-wide supported psychiatric risk variant in ncan influences brain function and cognitive performance in healthy subjects. Hum Brain Mapp 36 (1): 378-390.Dannlowski U, et al. (2015) Ncan cross-disorder risk variant is associated with limbic gray matter deficits in healthy subjects and major depression. Neuropsychopharmacology 40 (11): 2510-2516.