IF (Immunofluorescence)
(Immunofluorescence analysis of U20S cell using NCOA1 antibody. Blue: DAPI for nuclear staining.)
Rabbit NCOA1 Polyclonal Antibody | anti-NCOA1 antibody
NCOA1 antibody
Gene Names
NCOA1; SRC1; KAT13A; RIP160; F-SRC-1; bHLHe42; bHLHe74
Reactivity
Human, Mouse, Rat
Applications
Immunofluorescence, Western Blot
Purity
Antibodies were purified by affinity purification using immunogen.
Synonyms
NCOA1, Antibody; NCOA1 antibody; NCOA1; F-SRC-1; KAT13A; MGC129719; MGC129720; NCoA-1; RIP160; SRC-1; SRC1; bHLHe42; bHLHe74; anti-NCOA1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
The antibody detects endogenous level of total NCOA1 antibody.
Purity/Purification
Antibodies were purified by affinity purification using immunogen.
Form/Format
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
1441
Applicable Applications for anti-NCOA1 antibody
IF (Immunofluorescence), WB (Western Blot)
Immunogen Type
Recombinant Protein
Immunogen Description
Recombinant protein of human NCOA1.
Target Name
NCOA1
Preparation and Storage
Store at -20 degree C
IF (Immunofluorescence)
(Immunofluorescence analysis of U20S cell using NCOA1 antibody. Blue: DAPI for nuclear staining.)
IF (Immunofluorescence)
(Immunofluorescence analysis of U20S cell using NCOA1 antibody. Blue: DAPI for nuclear staining.)
WB (Western Blot)
(Western blot analysis of testis cell lysate using NCOA1 antibody.)
WB (Western Blot)
(Western blot analysis of testis cell lysate using NCOA1 antibody.)
Related Product Information for anti-NCOA1 antibody
There are three members of the steroid receptor co-activator (SRC) family of proteins: SRC-1 (NCoA-1), SRC-2 (TIF2/GRIP1/NCoA-2), and SRC-3 (ACTR/pCIP/RAC3/TRAM-1/AIB1). All SRC family members share significant structural homology and function to stimulate transcription mediated by nuclear hormone receptors and other transcriptional activators such as Stat3, NF-kB, E2F1, and p53 (1-4). Two SRC proteins, SRC-1 and SRC-3, function as histone acetyltransferases (5,6). In addition, all three family members can recruit other histone acetyltransferases (CBP/p300, PCAF) and histone methyltransferases (PRMT1, CARM1) to target promoters and cooperate to enhance expression of many genes (5-8). The SRC proteins play important roles in multiple physiological processes including cell proliferation, cell survival, somatic cell growth, mammary gland development, female reproductive function, and vasoprotection (9). SRC-1 and SRC-3 are conduits for kinase-mediated growth factor signaling to the estrogen receptor and other transcriptional activators. Seven SRC-1 phosphorylation sites and six SRC-3 phosphorylation sites have been identified, which are induced by steroids, cytokines, and growth factors and involve multiple kinase signaling pathways (9-11). Research has shown that all three SRC family members are associated with increased activity of nuclear receptors in breast, prostate, and ovarian carcinomas. According to the literature, SRC-3 is frequently amplified or overexpressed in a number of cancers (12), and SRC-1/PAX3 and SRC-2/MYST3 translocations are found associated with rhabdomyosarcoma and acute myeloid leukemia, respectively (13,14).
Product Categories/Family for anti-NCOA1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
157kd
NCBI Official Full Name
nuclear receptor coactivator 1 isoform 1
NCBI Official Synonym Full Names
nuclear receptor coactivator 1
NCBI Official Symbol
NCOA1
NCBI Official Synonym Symbols
SRC1; KAT13A; RIP160; F-SRC-1; bHLHe42; bHLHe74
NCBI Protein Information
nuclear receptor coactivator 1
UniProt Protein Name
Nuclear receptor coactivator 1
UniProt Gene Name
NCOA1
UniProt Synonym Gene Names
BHLHE74; SRC1; NCoA-1; bHLHe74; SRC-1
UniProt Entry Name
NCOA1_HUMAN
Similar Products
Product Notes
The NCOA1 ncoa1 (Catalog #AAA308272) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NCOA1 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's NCOA1 can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), WB (Western Blot). Researchers should empirically determine the suitability of the NCOA1 ncoa1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NCOA1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.