Rabbit NEUCRIN Polyclonal Antibody | anti-C1orf187 antibody

NEUCRIN Antibody

Cat. Num. AAA39917

• Gene Names: DRAXIN; UNQ3119; neucrin; AGPA3119; C1orf187
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: NEUCRIN Antibody is affinity chromatography purified via peptide column.
• Synonyms: NEUCRIN, Antibody; NEUCRIN Antibody; NEUCRIN; UNQ3119; neucrin; AGPA3119; C1orf187; PSEC0258; UNQ3119/PRO10268; Draxin; Dorsal inhibitory axon guidance protein; chromosome 1 open reading frame 187; anti-C1orf187 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: At least three isoforms of Neucrin are known to exist; this antibody will detect the two shorter isoforms. Neucrin antibody is predicted to not cross-react with RILP.
• Purity/Purification: NEUCRIN Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 349

• Applicable Applications for anti-C1orf187 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: Neucrin antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human Neucrin.
• Buffer: NEUCRIN Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: NEUCRIN antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of NEUCRIN in mouse brain tissue with NEUCRIN antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of NEUCRIN in mouse brain tissue with NEUCRIN antibody at 5 μg/mL.)

WB (Western Blot)

(Western blot analysis of Neucrin in rat cerebellum tissue lysate with Neucrin antibody at 1 μg/mL.)

Related Product Information for anti-C1orf187 antibody

NEUCRIN Antibody: Neucrin, also known as Draxin, is a repulsive guidance protein for the spinal cord and forebrain commissures. It is thought to act as an antagonist of canonical Wnt signaling by inhibiting the stabilization of cytosolic beta-catenin. Ectopically expressed neucrin inhibited growth or caused misrouting of chick spinal cord commissural axons in vivo while Neucrin-null mice showed defasciculation of spinal cord commissural axons and an absence of all forebrain commisures. Other experiments in mice have shown that olfactory bulb axonal outgrowth is inhibited by Neucrin, suggesting that Neucrin functions as an inhibitory guidance cue for olfactory bulb axons.

NCBI and Uniprot Product Information

• NCBI GI #: 86990448
• NCBI GeneID: 374946
• NCBI Accession #: BAG80561
• NCBI GenBank Nucleotide #: NM_198545.3
• UniProt Accession #: Q8NBI3; Q5SNX0; Q6UWK8; B6EV15
• Molecular Weight: 38,650 Da
• NCBI Official Full Name: draxin
• NCBI Official Synonym Full Names: dorsal inhibitory axon guidance protein
• NCBI Official Symbol: DRAXIN
• NCBI Official Synonym Symbols: UNQ3119; neucrin; AGPA3119; C1orf187
• NCBI Protein Information: draxin; dorsal repulsive axon guidance protein; dorsal inhibitory axon guidance protein; neural tissue-specific cysteine-rich protein
• UniProt Protein Name: Draxin
• UniProt Gene Name: DRAXIN
• UniProt Entry Name: DRAXI_HUMAN