Rabbit Neurofibromin / NF1 Polyclonal Antibody | anti-NF1 antibody

Rabbit Polyclonal (IgG) to Human Neurofibromin / NF1

Cat. Num. AAA51715

• Gene Names: NF1; WSS; NFNS; VRNF
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunofluorescence, Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: Neurofibromin / NF1, Antibody; Rabbit Polyclonal (IgG) to Human Neurofibromin / NF1; Anti-Neurofibromin / NF1 Antibody (aa1551-1600) IHC-plus; NF1; VRNF; Neurofibromin 1; NFNS; WSS; Neurofibromin; Human Neurofibromin; anti-NF1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: NF1 Antibody detects endogenous levels of total NF1 protein.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 2818

• Applicable Applications for anti-NF1 antibody: ELISA, WB (Western Blot), IF (Immunofluorescence), IHC (Immunohistochemistry)
• Target Species: Human
• Immunogen Description: Synthetic peptide from human NF1 (aa1551-1600).
• Immunogen: Neurofibromin / NF1 antibody was raised against synthetic peptide from human NF1 (aa1551-1600).
• Antigen Modification: aa1551-1600
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

WB (Western Blot)

(Western blot of extracts from HepG2 cells, using NF1 Antibody. The lane on the right is treated with the synthesized peptide.)

IF (Immunofluorescence)

(Immunofluorescence of HepG2 cells, using NF1 Antibody. The picture on the right is treated with the synthesized peptide.)

IHC (Immunohiostchemistry)

(Anti-NF1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.)

IHC (Immunohistochemistry)

(Anti-NF1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.)

Related Product Information for anti-NF1 antibody

Mutations linked to neurofibromatosis type 1 led to the identification of NF1. NF1 encodes the protein neurofibromin, which appears to be a negative regulator of the ras signal transduction pathway. In addition to type 1 neurofibromatosis, mutations in NF1 can also lead to juvenile myelomonocytic leukemia. Alternatively spliced NF1 mRNA transcripts have been isolated, although their functions, if any, remain unclear.

NCBI and Uniprot Product Information

• NCBI GI #: 4557793
• NCBI GeneID: 4763
• NCBI Accession #: NP_000258.1
• NCBI GenBank Nucleotide #: NM_000267.3
• UniProt Accession #: P21359; O00662; Q14284; Q14930; Q14931; Q9UMK3
• Molecular Weight: 318,992 Da
• NCBI Official Full Name: neurofibromin isoform 2
• NCBI Official Synonym Full Names: neurofibromin 1
• NCBI Official Symbol: NF1
• NCBI Official Synonym Symbols: WSS; NFNS; VRNF
• NCBI Protein Information: neurofibromin; neurofibromatosis-related protein NF-1
• UniProt Protein Name: Neurofibromin
• UniProt Gene Name: NF1
• UniProt Entry Name: NF1_HUMAN