Rabbit NMDAR1 Polyclonal Antibody | anti-NMDAR1 antibody

NMDAR1 (Phospho-Ser890) Antibody

Cat. Num. AAA305068

• Gene Names: GRIN1; NR1; MRD8; GluN1; NMDA1; NMD-R1; NMDAR1
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry
• Purity: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
• Synonyms: NMDAR1, Antibody; NMDAR1 (Phospho-Ser890) Antibody; GLURZ1; GRIN1; NMD-R1; NMDZ1; NMZ1; anti-NMDAR1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of NMDAR1 only when phosphorylated at serine 890.
• Purity/Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 885

• Applicable Applications for anti-NMDAR1 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry)
• Immunogen Type: Peptide-KLH
• Immunogen Description: Peptide sequence around phosphorylation site of Serine 890(A-S-S(p)-F-K) derived from Human NMDAR1.
• Modification: Phospho-Ser890
• Target Name: NMDAR1
• Preparation and Storage: Store at -20 degree C/1 year

IF (Immunofluorescence)

(Immunofluorescence staining of methanol-fixed A549 cells using NMDAR1 (Phospho-Ser890) Antibody.)

IHC (Immunohistochemistry)

(Immunohistochemical analysis of paraffin-embedded human brain tissue using NMDAR1 (Phospho-Ser890) antibody (left)or the same antibody preincubated with blocking peptide (right).)

Related Product Information for anti-NMDAR1 antibody

NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.

Product Categories/Family for anti-NMDAR1 antibody

Phospho-specific Ab

NCBI and Uniprot Product Information

• NCBI GI #: 11496971
• NCBI GeneID: 2902
• NCBI Accession #: NP_000823.4
• NCBI GenBank Nucleotide #: NM_000832.6
• UniProt Accession #: Q05586; P35437; Q12867; Q12868; Q5VSF3; Q5VSF4; Q5VSF5; Q5VSF6; Q5VSF7; A6NLK7; A6NLR1; C9K0X1
• Molecular Weight: 101,851 Da
• NCBI Official Full Name: glutamate receptor ionotropic, NMDA 1 isoform GluN1-4a
• NCBI Official Synonym Full Names: glutamate receptor, ionotropic, N-methyl D-aspartate 1
• NCBI Official Symbol: GRIN1
• NCBI Official Synonym Symbols: NR1; MRD8; GluN1; NMDA1; NMD-R1; NMDAR1
• NCBI Protein Information: glutamate receptor ionotropic, NMDA 1
• UniProt Protein Name: Glutamate receptor ionotropic, NMDA 1
• UniProt Gene Name: GRIN1
• UniProt Synonym Gene Names: NMDAR1; GluN1; NMD-R1
• UniProt Entry Name: NMDZ1_HUMAN