WB (Western Blot)
(NOG Antibody (Center) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the NOG antibody detected the NOG protein (arrow).)
Rabbit NOG Polyclonal Antibody | anti-NOG antibody
NOG Antibody (Center)
Gene Names
NOG; SYM1; SYNS1
Reactivity
Human, mouse (Predicted Reactivity: Rat)
Applications
ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
NOG, Antibody; NOG Antibody (Center); Noggin; NOG; anti-NOG antibody
Host
Rabbit
Reactivity
Human, mouse (Predicted Reactivity: Rat)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This NOG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-111 amino acids from the Central region of human NOG.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.32 (varies by lot)
Sequence Positions
84-111
Sequence Length
232
Applicable Applications for anti-NOG antibody
ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(NOG Antibody (Center) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the NOG antibody detected the NOG protein (arrow).)
WB (Western Blot)
(NOG Antibody (Center) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the NOG antibody detected the NOG protein (arrow).)
WB (Western Blot)
(NOG Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the NOG antibody detected the NOG protein (arrow).)
WB (Western Blot)
(NOG Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the NOG antibody detected the NOG protein (arrow).)
Related Product Information for anti-NOG antibody
The secreted polypeptide, encoded by this gene, binds and
inactivates members of the transforming growth factor-beta
(TGF-beta) superfamily signaling proteins, such as bone
morphogenetic protein-4 (BMP4). By diffusing through extracellular
matrices more efficiently than members of the TGF-beta superfamily,
this protein may have a principal role in creating morphogenic
gradients. The protein appears to have pleiotropic effect, both
early in development as well as in later stages. It was originally
isolated from Xenopus based on its ability to restore normal
dorsal-ventral body axis in embryos that had been artificially
ventralized by UV treatment. The results of the mouse knockout of
the ortholog suggest that it is involved in numerous developmental
processes, such as neural tube fusion and joint formation.
Recently, several dominant human NOG mutations in unrelated
families with proximal symphalangism (SYM1) and multiple synostoses
syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple
joint fusion as their principal feature, and map to the same region
(17q22) as this gene. All of these mutations altered evolutionarily
conserved amino acid residues. The amino acid sequence of this
human gene is highly homologous to that of Xenopus, rat and mouse.
inactivates members of the transforming growth factor-beta
(TGF-beta) superfamily signaling proteins, such as bone
morphogenetic protein-4 (BMP4). By diffusing through extracellular
matrices more efficiently than members of the TGF-beta superfamily,
this protein may have a principal role in creating morphogenic
gradients. The protein appears to have pleiotropic effect, both
early in development as well as in later stages. It was originally
isolated from Xenopus based on its ability to restore normal
dorsal-ventral body axis in embryos that had been artificially
ventralized by UV treatment. The results of the mouse knockout of
the ortholog suggest that it is involved in numerous developmental
processes, such as neural tube fusion and joint formation.
Recently, several dominant human NOG mutations in unrelated
families with proximal symphalangism (SYM1) and multiple synostoses
syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple
joint fusion as their principal feature, and map to the same region
(17q22) as this gene. All of these mutations altered evolutionarily
conserved amino acid residues. The amino acid sequence of this
human gene is highly homologous to that of Xenopus, rat and mouse.
Product Categories/Family for anti-NOG antibody
References
Rudnik-Schoneborn, S., et al. Am. J. Med. Genet. A 152A (6), 1540-1544 (2010) :
Song, K., et al. J. Biol. Chem. 285(16):12169-12180(2010)
Mangold, E., et al. Nat. Genet. 42(1):24-26(2010)
Gutierrez, S.J., et al. Acta Odontol Latinoam 23(1):13-19(2010)
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
Song, K., et al. J. Biol. Chem. 285(16):12169-12180(2010)
Mangold, E., et al. Nat. Genet. 42(1):24-26(2010)
Gutierrez, S.J., et al. Acta Odontol Latinoam 23(1):13-19(2010)
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
25774
NCBI Official Full Name
noggin
NCBI Official Synonym Full Names
noggin
NCBI Official Symbol
NOG
NCBI Official Synonym Symbols
SYM1; SYNS1
NCBI Protein Information
noggin
UniProt Protein Name
Noggin
UniProt Gene Name
NOG
UniProt Entry Name
NOGG_HUMAN
Similar Products
Product Notes
The NOG nog (Catalog #AAA288140) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 84-111. The NOG Antibody (Center) reacts with Human, mouse (Predicted Reactivity: Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's NOG can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the NOG nog for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NOG, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.