ICC (Immunocytochemistry)
(Immunocytochemistry of Norrin in Jurkat cells with Norrin antibody at 5 μg/mL.)
Rabbit anti-Human Norrin Polyclonal Antibody | anti-NDP antibody
Norrin Antibody
Gene Names
NDP; ND; EVR2; FEVR
Reactivity
Human
Applications
Immunocytochemistry, Western Blot, ELISA
Purity
Norrin Antibody is affinity chromatography purified via peptide column.
Synonyms
Norrin, Antibody; Norrin Antibody; Norrin; ND; EVR2; FEVR; Norrie disease protein; Norrie disease (pseudoglioma); anti-NDP antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Norrin Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
133
Applicable Applications for anti-NDP antibody
ICC (Immunocytochemistry), WB (Western Blot), ELISA
Conjugate
Unconjugated
Immunogen
Norrin antibody was raised against an 18 amino acid synthetic peptide from near the amino terminus of human Norrin.
Buffer
Norrin Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
ICC (Immunocytochemistry)
(Immunocytochemistry of Norrin in Jurkat cells with Norrin antibody at 5 μg/mL.)
ICC (Immunocytochemistry)
(Immunocytochemistry of Norrin in Jurkat cells with Norrin antibody at 5 μg/mL.)
WB (Western Blot)
(Western blot analysis of Norrin in Jurkat cell lysate with Norrin antibody at (A) 1 and (B) 2 μg/mL.)
WB (Western Blot)
(Western blot analysis of Norrin in Jurkat cell lysate with Norrin antibody at (A) 1 and (B) 2 μg/mL.)
Related Product Information for anti-NDP antibody
Norrin Antibody: Norrie disease is an X-linked genetic disorder characterized by progressive atrophy of the eyes, mental disturbances and deafness. The gene responsible for this disease was initially identified through positional cloning. Norrin, the gene product, encodes a small secreted, cysteine-rich protein that is thought to act as a ligand for the Wnt-receptor/beta-catenin signal pathway despite having sequence homology with the Wnt family of proteins. Mice lacking this gene have abnormal blood vessel growth in the vitreous and a disorganized retina; transgenic ectopic expression of Norrin restores normal retinal vasculature. Recent evidence shows that Norrin can attenuate tPA and uPA-mediated death of transformed rat retinal ganglion cells (RGC-5) by activating the Wnt/beta-catenin pathway and regulating the phosphorylation of LRP-1, a cell surface receptor for tPA and uPA, suggesting the Norrin may function in vivo by regulating kinases which may alter the phosphorylation of LRP-1.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
15,044 Da
NCBI Official Full Name
norrin
NCBI Official Synonym Full Names
Norrie disease (pseudoglioma)
NCBI Official Symbol
NDP
NCBI Official Synonym Symbols
ND; EVR2; FEVR
NCBI Protein Information
norrin; norrie disease protein; X-linked exudative vitreoretinopathy 2 protein
UniProt Protein Name
Norrin
UniProt Gene Name
NDP
UniProt Synonym Gene Names
EVR2
UniProt Entry Name
NDP_HUMAN
Similar Products
Product Notes
The NDP ndp (Catalog #AAA39546) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Norrin Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Norrin can be used in a range of immunoassay formats including, but not limited to, ICC (Immunocytochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the NDP ndp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Norrin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.