IHC (Immunohiostchemistry)
(Immunohistochemistry of NOTUM in human brain tissue with NOTUM antibody at 2.5 ug/mL.)
Rabbit NOTUM Polyclonal Antibody | anti-NOTUM antibody
NOTUM Antibody
Gene Names
NOTUM; hNOTUM
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
NOTUM, Antibody; NOTUM Antibody; NOTUM pectinacetylesterase homolog; anti-NOTUM antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
496
Applicable Applications for anti-NOTUM antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a 19 amino acid peptide near the amino terminus of human NOTUM.
Target Name
NOTUM
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IHC (Immunohiostchemistry)
(Immunohistochemistry of NOTUM in human brain tissue with NOTUM antibody at 2.5 ug/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of NOTUM in human brain tissue with NOTUM antibody at 2.5 ug/mL.)
WB (Western Blot)
(Western blot analysis of NOTUM in human kidney tissue lysate with NOTUM antibody at (A) 0.5 and (B) 1 ug/mL.)
WB (Western Blot)
(Western blot analysis of NOTUM in human kidney tissue lysate with NOTUM antibody at (A) 0.5 and (B) 1 ug/mL.)
Related Product Information for anti-NOTUM antibody
In Drosophila, the notum gene is regulated by the Wingless pathway and encodes a secreted hydrolase that modifies heparan sulfate proteoglycans. The mammalian homolog has been shown to be able to cleave glypicans and can release GPI-anchored proteins from the mammalian cell surface. Like the Drosophilia NOTUM, the mammalian protein can act as a negative regulator of the Wnt signaling pathway. NOTUM is expressed at a low level in most mammalian tissues, although it is overexpressed in a subset of human hepatocellular carcinomas. Its transcription is regulated by beta-catenin/TCF and is a target of the Wnt signaling pathway, forming a negative feedback loop that regulates the expression and activity of the Wnt pathway.
Product Categories/Family for anti-NOTUM antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
55,699 Da
NCBI Official Full Name
palmitoleoyl-protein carboxylesterase NOTUM
NCBI Official Synonym Full Names
notum pectinacetylesterase homolog (Drosophila)
NCBI Official Symbol
NOTUM
NCBI Official Synonym Symbols
hNOTUM
NCBI Protein Information
palmitoleoyl-protein carboxylesterase NOTUM
UniProt Protein Name
Palmitoleoyl-protein carboxylesterase NOTUM
UniProt Gene Name
NOTUM
UniProt Entry Name
NOTUM_HUMAN
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Product Notes
The NOTUM notum (Catalog #AAA307870) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NOTUM Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's NOTUM can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the NOTUM notum for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NOTUM, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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