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IHC (Immunohistochemistry)
(NR0B2 Antibody-Breast, carcinoma)
Rabbit anti-Human NR0B2 Polyclonal Antibody | anti-NR0B2 antibody
NR0B2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Gene Names
NR0B2; SHP; SHP1
Reactivity
Human
Applications
Immunohistochemistry, Immunohistochemistry
Purity
Immunoaffinity purified
Synonyms
NR0B2, Antibody; NR0B2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody; PathPlus NR0B2 Antibody (C-Terminus); NR0B2; Short heterodimer partner; SHP; Nuclear receptor SHP; Orphan nuclear receptor SHP; Small heterodimer partner; SHP1; anti-NR0B2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
Human NR0B2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.1% Sodium Azide
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-NR0B2 antibody
IHC (Immunohistochemistry), IHC (Immunohistochemistry)
Target
Human NR0B2
Immunogen
Synthetic 14 amino acid peptide near C-Terminus of human NR0B2. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Orangutan, Gibbon, Monkey, Marmoset (100%); Gorilla, Tamarin, Bat (93%); Hamster, Panda, Rabbit, Horse (86%).
Conjugation
Unconjugated
Epitope
C-Terminus
Family
NHR
Subfamily
NR0 Knirps-like
Preparation and Storage
Aliquot and store undiluted at -20 degree C or below for up to 1 year. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze-thaw cycles.
IHC (Immunohistochemistry)
(NR0B2 Antibody-Breast, carcinoma)
IHC (Immunohistochemistry)
(NR0B2 Antibody-Breast, carcinoma)
IHC (Immunohistochemisry)
(NR0B2 Antibody-Anti-NR0B2 antibody IHC staining of human liver, hepatocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
IHC (Immunohistochemisry)
(NR0B2 Antibody-Anti-NR0B2 antibody IHC staining of human liver, hepatocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
IHC (Immunohiostchemistry)
(NR0B2 Antibody-Pancreas, carcinoma)
IHC (Immunohiostchemistry)
(NR0B2 Antibody-Pancreas, carcinoma)
IHC (Immunohistochemistry)
(NR0B2 Antibody-Ovary, carcinoma)
IHC (Immunohistochemistry)
(NR0B2 Antibody-Ovary, carcinoma)
Related Product Information for anti-NR0B2 antibody
NR0B2 antibody is an unconjugated rabbit polyclonal antibody to NR0B2 (C-Terminus) from human. Validated for IHC.
SHP (short heterodimer partner) is a bile acid-dependent orphan NR0 Knirps-Like receptor with dimerization and ligand-binding domains but not the conventional DNA-binding domain. SHP has been shown to inhibit the transcriptional activity of other nuclear receptors, including thyroid hormone receptor, constitutive androstane receptor, and retinoic acid receptors. SHP affects hepatic cholesterol catabolism based on a two-step mechanism dependent on both coactivator competition and direct transcriptional repression by mediating the repression of CYP7A1, the rate-limiting enzyme for bile acid synthesis. Mutations in the SHP gene contribute to increased body weight, indicating a possible role of SHP in the development of early-onset diabetes (maturity-onset diabetes of the young, MODY). Loss of SHP in mice caused abnormal accumulation and increased synthesis of bile acids due to derepression of rate-limiting CYP7A1 and CYP8B1 hydroxylase enzymes in the biosynthetic pathway.
SHP (short heterodimer partner) is a bile acid-dependent orphan NR0 Knirps-Like receptor with dimerization and ligand-binding domains but not the conventional DNA-binding domain. SHP has been shown to inhibit the transcriptional activity of other nuclear receptors, including thyroid hormone receptor, constitutive androstane receptor, and retinoic acid receptors. SHP affects hepatic cholesterol catabolism based on a two-step mechanism dependent on both coactivator competition and direct transcriptional repression by mediating the repression of CYP7A1, the rate-limiting enzyme for bile acid synthesis. Mutations in the SHP gene contribute to increased body weight, indicating a possible role of SHP in the development of early-onset diabetes (maturity-onset diabetes of the young, MODY). Loss of SHP in mice caused abnormal accumulation and increased synthesis of bile acids due to derepression of rate-limiting CYP7A1 and CYP8B1 hydroxylase enzymes in the biosynthetic pathway.
References
The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
28,058 Da
NCBI Official Full Name
nuclear receptor subfamily 0 group B member 2
NCBI Official Synonym Full Names
nuclear receptor subfamily 0, group B, member 2
NCBI Official Symbol
NR0B2
NCBI Official Synonym Symbols
SHP; SHP1
NCBI Protein Information
nuclear receptor subfamily 0 group B member 2; nuclear receptor SHP; small heterodimer partner; orphan nuclear receptor SHP
UniProt Protein Name
Nuclear receptor subfamily 0 group B member 2
UniProt Gene Name
NR0B2
UniProt Synonym Gene Names
SHP
UniProt Entry Name
NR0B2_HUMAN
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Product Notes
The NR0B2 nr0b2 (Catalog #AAA162462) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NR0B2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NR0B2 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the NR0B2 nr0b2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NR0B2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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