Rabbit OPRS1 Polyclonal Antibody | anti-SIGMAR1 antibody

OPRS1 Antibody (Center)

Cat. Num. AAA284234

• Gene Names: SIGMAR1; SRBP; ALS16; OPRS1; SR-BP; SIG-1R; SR-BP1; sigma1R; hSigmaR1
• Reactivity: Human, mouse (Predicted Reactivity: Bovine)
• Applications: ELISA, Western Blot
• Purity: Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: OPRS1, Antibody; OPRS1 Antibody (Center); Sigma non-opioid intracellular receptor 1; Aging-associated gene 8 protein; SR31747-binding protein; SR-BP; Sigma 1-type opioid receptor; SIG-1R; Sigma1-receptor; Sigma1R; hSigmaR1; SIGMAR1; OPRS1; SRBP; anti-SIGMAR1 antibody

• Host: Rabbit
• Reactivity: Human, mouse (Predicted Reactivity: Bovine)
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This OPRS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-147 amino acids from the Central region of human OPRS1.
• Purity/Purification: Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Sequence Positions: 118-147
• Sequence Length: 187

• Applicable Applications for anti-SIGMAR1 antibody: ELISA, WB (Western Blot)
• Function: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity).
• Cellular Location: Nucleus inner membrane. Nucleus outer membrane. Nucleus envelope. Cytoplasmic vesicle. Endoplasmic reticulum membrane. Membrane; Single-pass membrane protein. Lipid droplet {ECO:0000250|UniProtKB:O55242}. Cell junction. Cell membrane. Cell projection, growth cone. Cell junction, synapse, postsynaptic density membrane. Note=During interphase, detected at the inner and outer nuclear membrane and the endoplasmic reticulum Detected on cytoplasmic vesicles during mitosis (PubMed:10406945) Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Accumulation at the endoplasmic reticulum is prominent in alpha-motor neurons of patients with amyotrophic lateral sclerosis (PubMed:23314020). Enriched at cell-cell communication regions, growth cone and postsynaptic structures Localization is modulated by ligand-binding. In motor neurons it is enriched at cholinergic postsynaptic densities (By similarity) {ECO:0000250|UniProtKB:O55242, ECO:0000269|PubMed:10406945, ECO:0000269|PubMed:23314020}
• Tissue Location: Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas Expressed in the retina by retinal pigment epithelial cells. Expressed in alpha-motor neurons (PubMed:23314020).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

WB (Western Blot)

(OPRS1 Antibody (Center) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the OPRS1 antibody detected the OPRS1 protein (arrow).)

WB (Western Blot)

(Western blot analysis of OPRS1 (arrow) using rabbit polyclonal OPRS1 Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the OPRS1 gene (Lane 2) (Origene Technologies).)

Related Product Information for anti-SIGMAR1 antibody

OPRS1 is a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems.

Product Categories/Family for anti-SIGMAR1 antibody

Cancer; Cardiovascular; Neuroscience; Signal transduction

References

Cobos,E.J.,J. Neurochem. 102 (3), 812-825 (2007)
Maurice,T., Pharmacol. Biochem. Behav. 84 (4), 581-597 (2006)
Lee,I.T.,Eur. J. Pharmacol. 578 (2-3), 123-136 (2008)

NCBI and Uniprot Product Information

• NCBI GI #: 532524982
• NCBI GeneID: 10280
• NCBI Accession #: NP_001269134.1; NP_001269135.1; NP_001269136.1; NP_001269137.1; NP_001269138.1; NP_005857.1; NP_671513.1
• NCBI GenBank Nucleotide #: NM_001282205.1
• UniProt Accession #: Q99720; O00673; O00725; Q0Z9W6; Q153Z1; Q2TSD1; Q53GN2; Q7Z653; Q8N7H3; Q9NYX0; D3DRM7
• Molecular Weight: 25128
• NCBI Official Full Name: sigma non-opioid intracellular receptor 1 isoform 6
• NCBI Official Synonym Full Names: sigma non-opioid intracellular receptor 1
• NCBI Official Symbol: SIGMAR1
• NCBI Official Synonym Symbols: SRBP; ALS16; OPRS1; SR-BP; SIG-1R; SR-BP1; sigma1R; hSigmaR1
• NCBI Protein Information: sigma non-opioid intracellular receptor 1
• UniProt Protein Name: Sigma non-opioid intracellular receptor 1
• UniProt Gene Name: SIGMAR1
• UniProt Synonym Gene Names: OPRS1; SRBP; SR-BP; SIG-1R; Sigma1-receptor; Sigma1R; hSigmaR1
• UniProt Entry Name: SGMR1_HUMAN