WB (Western Blot)
(Western blot analysis of lysate from HT-1080 cell line,using OPTC Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.)
Rabbit OPTC Polyclonal Antibody | anti-OPTC antibody
OPTC Antibody
Gene Names
OPTC; OPT
Reactivity
Human, mouse, rat
Applications
ELISA, Western Blot
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
OPTC, Antibody; OPTC Antibody; Opticin; Oculoglycan; OPTC; OPT; anti-OPTC antibody
Host
Rabbit
Reactivity
Human, mouse, rat
Clonality
Polyclonal
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Sequence Positions
269-329
Sequence Length
332
Applicable Applications for anti-OPTC antibody
ELISA, WB (Western Blot)
Function
Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity).
Cellular Location
Secreted, extracellular space, extracellular matrix
Tissue Location
Expressed in cartilage and synovial membranes (at protein level) (PubMed:18164633, PubMed:23845380). Expressed in the retina, iris, ligament, skin and fetal liver (at protein level) (PubMed:12019215, PubMed:25136834). Expressed in the retinal pigment epithelium (at protein level) (PubMed:25136834). Expressed in synovial fibroblasts and subchondral bone osteoblasts (PubMed:18164633) Provided below are standard protocols that you may find useful for product applications.
Preparation and Storage
Store at -20°C.Stable for 12 months from date of receipt
WB (Western Blot)
(Western blot analysis of lysate from HT-1080 cell line,using OPTC Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.)
WB (Western Blot)
(Western blot analysis of lysate from HT-1080 cell line,using OPTC Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.)
Related Product Information for anti-OPTC antibody
Binds collagen fibrils (By similarity).
Product Categories/Family for anti-OPTC antibody
References
Reardon A.J.,et al.J. Biol. Chem. 275:2123-2129(2000).
Hobby P.,et al.Mol. Vis. 6:72-78(2000).
Friedman J.S.,et al.Invest. Ophthalmol. Vis. Sci. 41:2059-2066(2000).
Friedman J.S.,et al.Hum. Mol. Genet. 11:1333-1342(2002).
Gregory S.G.,et al.Nature 441:315-321(2006).
Hobby P.,et al.Mol. Vis. 6:72-78(2000).
Friedman J.S.,et al.Invest. Ophthalmol. Vis. Sci. 41:2059-2066(2000).
Friedman J.S.,et al.Hum. Mol. Genet. 11:1333-1342(2002).
Gregory S.G.,et al.Nature 441:315-321(2006).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
37kDa
NCBI Official Full Name
opticin
NCBI Official Synonym Full Names
opticin
NCBI Official Symbol
OPTC
NCBI Official Synonym Symbols
OPT
NCBI Protein Information
opticin
UniProt Protein Name
Opticin
UniProt Gene Name
OPTC
UniProt Synonym Gene Names
OPT
UniProt Entry Name
OPT_HUMAN
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Product Notes
The OPTC optc (Catalog #AAA284699) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 269-329. The OPTC Antibody reacts with Human, mouse, rat and may cross-react with other species as described in the data sheet. AAA Biotech's OPTC can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the OPTC optc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "OPTC, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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