IF (Immunofluorescence)
(Immunofluorescence of OTUD5 in Human Kidney cells with OTUD5 antibody at 20 μg/mL.)
Rabbit OTUD5 Polyclonal Antibody | anti-OTUD5 antibody
OTUD5 Antibody
Gene Names
OTUD5; DUBA
Reactivity
Human, Mouse, Rat
Applications
Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
Purity
OTUD5 Antibody is affinity chromatography purified via peptide column.
Synonyms
OTUD5, Antibody; OTUD5 Antibody; OTUD5; DUBA; OTU domain-containing protein 5; Deubiquitinating enzyme A; OTU domain containing 5; anti-OTUD5 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
OTUD5 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
641
Applicable Applications for anti-OTUD5 antibody
IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
Conjugate
Unconjugated
Immunogen
OTUD5 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of the human OTUD5.
Buffer
OTUD5 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
OTUD5 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IF (Immunofluorescence)
(Immunofluorescence of OTUD5 in Human Kidney cells with OTUD5 antibody at 20 μg/mL.)
IF (Immunofluorescence)
(Immunofluorescence of OTUD5 in Human Kidney cells with OTUD5 antibody at 20 μg/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of OTUD5 in mouse kidney tissue with OTUD5 antibody at 2.5 μg/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of OTUD5 in mouse kidney tissue with OTUD5 antibody at 2.5 μg/mL.)
WB (Western Blot)
(Western blot analysis of OTUD5 in human kidney lysate with OTUD5 antibody at (A) 1 and (B) 2 μg/mL.)
WB (Western Blot)
(Western blot analysis of OTUD5 in human kidney lysate with OTUD5 antibody at (A) 1 and (B) 2 μg/mL.)
Related Product Information for anti-OTUD5 antibody
OTUD5 Antibody: OTUD5 is a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and OTUD5 has been shown to suppress the type I interferon (IFN-I)-dependent innate immune response by cleaving the polyubiquitin chain from TRAF3, an essential type I interferon adaptor protein. Cleavage results in disassociation of TRAF3 from a downstream signaling complex containing TBK1 and the disruption of the IFN-I signaling cascade, indicating that OTUD5 acts as a negative regulator of innate immune responses. It has been suggested that by suppressing IFN-I production, OTUD5 may function to inhibit the emergence of certain autoimmune disorders such as systemic lupus erythematosus. Multiple isoforms of OTUD5 are known to exist.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
60,210 Da
NCBI Official Full Name
OTU domain containing 5, isoform CRA_b
NCBI Official Synonym Full Names
OTU deubiquitinase 5
NCBI Official Symbol
OTUD5
NCBI Official Synonym Symbols
DUBA
NCBI Protein Information
OTU domain-containing protein 5; OTU domain containing 5; deubiquinating enzyme A; deubiquitinating enzyme A
UniProt Protein Name
OTU domain-containing protein 5
UniProt Gene Name
OTUD5
UniProt Synonym Gene Names
DUBA
UniProt Entry Name
OTUD5_HUMAN
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Product Notes
The OTUD5 otud5 (Catalog #AAA39592) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The OTUD5 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's OTUD5 can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the OTUD5 otud5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "OTUD5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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