IHC (Immunohistochemisry)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Rabbit anti-Human Pael-R (GPR37) Polyclonal Antibody | anti-GPR37 antibody
Pael-R (GPR37) Antibody (C-term)
Gene Names
GPR37; PAELR; EDNRBL; hET(B)R-LP
Reactivity
Human
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
Pael-R (GPR37), Antibody; Pael-R (GPR37) Antibody (C-term); Prosaposin receptor GPR37; Endothelin B receptor-like protein 1; ETBR-LP-1; G-protein coupled receptor 37; Parkin-associated endothelin receptor-like receptor; PAELR; GPR37; anti-GPR37 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This Pael-R (GPR37) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-246 amino acids from the C-terminal region of human Pael-R (GPR37).
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
217-246
Sequence Length
613
Applicable Applications for anti-GPR37 antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohistochemisry)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
IHC (Immunohistochemisry)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
WB (Western Blot)
(Western blot analysis of anti-Pael-R (GPR37) Pab in mouse brain tissue lysate. Pael-R (GPR37) (arrow) was detected using the purified Pab.)
WB (Western Blot)
(Western blot analysis of anti-Pael-R (GPR37) Pab in mouse brain tissue lysate. Pael-R (GPR37) (arrow) was detected using the purified Pab.)
WB (Western Blot)
(Western blot analysis of anti-Pael-R (GPR37) Antibody (C-term) in K562 cell line lysates (35ug/lane). Pael-R (arrow) was detected using the purified Pab.)
WB (Western Blot)
(Western blot analysis of anti-Pael-R (GPR37) Antibody (C-term) in K562 cell line lysates (35ug/lane). Pael-R (arrow) was detected using the purified Pab.)
Related Product Information for anti-GPR37 antibody
Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known; however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function. Panneuronal expression of Parkin substrate Pael-R causes age-dependent selective degeneration of Drosophila dopaminergic (DA) neurons; coexpression of Parkin degrades Pael-R and suppresses its toxicity.
Product Categories/Family for anti-GPR37 antibody
References
Yang,Y., et al. Neuron 37 (6), 911-924 (2003)
Imai,Y., et al. Mol. Cell 10 (1), 55-67 (2002)
Imai,Y., et al. Cell 105 (7), 891-902 (2001)
Marazziti,D., et al. Genomics 45 (1), 68-77 (1997)
Zeng,Z., et al. BBRC 233 (2), 559-567 (1997)
Imai,Y., et al. Mol. Cell 10 (1), 55-67 (2002)
Imai,Y., et al. Cell 105 (7), 891-902 (2001)
Marazziti,D., et al. Genomics 45 (1), 68-77 (1997)
Zeng,Z., et al. BBRC 233 (2), 559-567 (1997)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
67114
NCBI Official Full Name
prosaposin receptor GPR37
NCBI Official Synonym Full Names
G protein-coupled receptor 37 (endothelin receptor type B-like)
NCBI Official Symbol
GPR37
NCBI Official Synonym Symbols
PAELR; EDNRBL; hET(B)R-LP
NCBI Protein Information
prosaposin receptor GPR37
UniProt Protein Name
Prosaposin receptor GPR37
UniProt Gene Name
GPR37
UniProt Synonym Gene Names
ETBR-LP-1; PAELR
UniProt Entry Name
GPR37_HUMAN
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Product Notes
The GPR37 gpr37 (Catalog #AAA289950) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 217-246. The Pael-R (GPR37) Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Pael-R (GPR37) can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the GPR37 gpr37 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Pael-R (GPR37), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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