WB (Western Blot)
(PAPD5 Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the PAPD5 Antibody detected the PAPD5 protein (arrow).)
Rabbit anti-Human PAPD5 Polyclonal Antibody | anti-PAPD5 antibody
PAPD5 Antibody (N-term)
Gene Names
PAPD5; TRF4-2
Reactivity
Human
Applications
ELISA, Western Blot
Synonyms
PAPD5, Antibody; PAPD5 Antibody (N-term); Non-canonical poly(A) RNA polymerase PAPD5; PAP-associated domain-containing protein 5; Terminal uridylyltransferase 3; TUTase 3; Topoisomerase-related function protein 4-2; TRF4-2; PAPD5; anti-PAPD5 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This PAPD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PAPD5.
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Sequence Positions
1-30
Sequence Length
698
Applicable Applications for anti-PAPD5 antibody
ELISA, WB (Western Blot)
Function
Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion.
Cellular Location
Nucleus. Nucleus, nucleolus. Cytoplasm. Note=Predominantly expressed in the cytoplasm (PubMed:18172165)
Preparation and Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
WB (Western Blot)
(PAPD5 Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the PAPD5 Antibody detected the PAPD5 protein (arrow).)
WB (Western Blot)
(PAPD5 Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the PAPD5 Antibody detected the PAPD5 protein (arrow).)
Related Product Information for anti-PAPD5 antibody
PAPD5 plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Mullen, T.E., et al. Genes Dev. 22(1):50-65(2008)
Walowsky, C., et al. J. Biol. Chem. 274(11):7302-7308(1999)
Mullen, T.E., et al. Genes Dev. 22(1):50-65(2008)
Walowsky, C., et al. J. Biol. Chem. 274(11):7302-7308(1999)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
non-canonical poly(A) RNA polymerase PAPD5 isoform a
NCBI Official Synonym Full Names
PAP associated domain containing 5
NCBI Official Symbol
PAPD5
NCBI Official Synonym Symbols
TRF4-2
NCBI Protein Information
non-canonical poly(A) RNA polymerase PAPD5
UniProt Protein Name
Non-canonical poly(A) RNA polymerase PAPD5
UniProt Gene Name
PAPD5
UniProt Synonym Gene Names
TUTase 3; TRF4-2
UniProt Entry Name
PAPD5_HUMAN
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Product Notes
The PAPD5 papd5 (Catalog #AAA288755) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-30. The PAPD5 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PAPD5 can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the PAPD5 papd5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PAPD5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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