Rabbit papillomavirus type 16 Protein E6 Polyclonal Antibody | anti-E6 antibody
Rabbit anti-human papillomavirus type 16 Protein E6 polyclonal Antibody, Biotin conjugated
Reactivity
Human papillomavirus type 16
Applications
ELISA
Purity
>95%, Protein G purified
Synonyms
papillomavirus type 16 Protein E6, Antibody; Rabbit anti-human papillomavirus type 16 Protein E6 polyclonal Antibody, Biotin conjugated; Protein E6, E6; anti-E6 antibody
Host
Rabbit
Reactivity
Human papillomavirus type 16
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Sequence Length
158
Applicable Applications for anti-E6 antibody
ELISA
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Immunogen
Recombinant Human papillomavirus type 16 Protein E6 protein (1-158AA)
Research Area
Microbiology
Target Names
E6
Conjugate
Biotin
Preparation and Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Related Product Information for anti-E6 antibody
Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including Bak, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
transforming protein
NCBI Official Symbol
E6
NCBI Protein Information
transforming protein
UniProt Protein Name
Protein E6
UniProt Gene Name
E6
UniProt Entry Name
VE6_HPV16
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Product Notes
The E6 e6 (Catalog #AAA117859) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human papillomavirus type 16 Protein E6 polyclonal Antibody, Biotin conjugated reacts with Human papillomavirus type 16 and may cross-react with other species as described in the data sheet. AAA Biotech's papillomavirus type 16 Protein E6 can be used in a range of immunoassay formats including, but not limited to, ELISA. Researchers should empirically determine the suitability of the E6 e6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "papillomavirus type 16 Protein E6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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