IHC (Immunohiostchemistry)
(PCCA Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PCCA Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit anti-Human PCCA Polyclonal Antibody | anti-PCCA antibody
PCCA Antibody (Center)
Reactivity
Human
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
PCCA, Antibody; PCCA Antibody (Center); Propionyl-CoA carboxylase alpha chain; mitochondrial; PCCase subunit alpha; Propanoyl-CoA:carbon dioxide ligase subunit alpha; PCCA; anti-PCCA antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This PCCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 362-390 amino acids from the Central region of human PCCA.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
362-390
Sequence Length
681
Applicable Applications for anti-PCCA antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(PCCA Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PCCA Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(PCCA Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PCCA Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(PCCA Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PCCA antibody detected the PCCA protein (arrow).)
WB (Western Blot)
(PCCA Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PCCA antibody detected the PCCA protein (arrow).)
Related Product Information for anti-PCCA antibody
The protein encoded by this gene is the alpha subunit of
the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase.
PCCA encodes the biotin-binding region of this enzyme. Mutations in
either PCCA or PCCB (encoding the beta subunit) lead to an enzyme
deficiency resulting in propionic acidemia. Multiple transcript
variants encoding different isoforms have been found for this gene.
the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase.
PCCA encodes the biotin-binding region of this enzyme. Mutations in
either PCCA or PCCB (encoding the beta subunit) lead to an enzyme
deficiency resulting in propionic acidemia. Multiple transcript
variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-PCCA antibody
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Huang, C.S., et al. Nature 466(7309):1001-1005(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
MacDonald, M.J., et al. Diabetologia 52(6):1087-1091(2009)
Huang, C.S., et al. Nature 466(7309):1001-1005(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
MacDonald, M.J., et al. Diabetologia 52(6):1087-1091(2009)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
80059
NCBI Official Full Name
propionyl-CoA carboxylase alpha chain, mitochondrial isoform a
NCBI Official Synonym Full Names
propionyl CoA carboxylase, alpha polypeptide
NCBI Official Symbol
PCCA
NCBI Protein Information
propionyl-CoA carboxylase alpha chain, mitochondrial
UniProt Protein Name
Propionyl-CoA carboxylase alpha chain, mitochondrial
UniProt Gene Name
PCCA
UniProt Synonym Gene Names
PCCase subunit alpha
UniProt Entry Name
PCCA_HUMAN
Similar Products
Product Notes
The PCCA pcca (Catalog #AAA289550) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 362-390. The PCCA Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PCCA can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the PCCA pcca for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PCCA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.