Rabbit anti-Human, Mouse PD-1 Polyclonal Antibody | anti-PDCD1 antibody

PD-1 Antibody

Cat. Num. AAA40106

• Gene Names: PDCD1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1
• Reactivity: Human, Mouse
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: PD-1 Antibody is affinity chromatography purified via peptide column.
• Synonyms: PD-1, Antibody; PD-1 Antibody; PD-1; PD1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; Programmed cell death protein 1; Protein PD-1; PDCD1; PDCD-1; programmed cell death 1; anti-PDCD1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: PD-1 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 288

• Applicable Applications for anti-PDCD1 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: PD-1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human PD-1.
• Buffer: PD-1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: PD-1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

WB (Western Blot)

(Western blot analysis of PD-1 in rat thymus cell lysate with PD-1 antibody at 1 μg/mL.)

IHC (Immunohistochemistry)

(Immunohistochemistry of PD-1 in human brain tissue with PD-1 antibody at 2.5 μg/mL.)

IF (Immunofluorescence)

(Immunofluorescence of PD-1 in Human Brain tissue with PD-1 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of PD-1 in human tonsil tissue with PD-1 antibody at 5 μg/mL.)

WB (Western Blot)

(Western blot analysis of PD-1 in THP-1 cell lysate with PD-1 antibody at 1 μg/mL in the (A) absence and (B) presence of blocking peptide.)

Related Product Information for anti-PDCD1 antibody

PD-1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases.

NCBI and Uniprot Product Information

• NCBI GI #: 145559515
• NCBI GeneID: 5133
• UniProt Accession #: Q15116; O00517; Q8IX89
• Molecular Weight: Predicted: 32 kDa; ; Observed: 45 kDa
• NCBI Official Full Name: Programmed cell death protein 1
• NCBI Official Synonym Full Names: programmed cell death 1
• NCBI Official Symbol: PDCD1
• NCBI Official Synonym Symbols: PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1
• NCBI Protein Information: programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2
• UniProt Protein Name: Programmed cell death protein 1
• UniProt Gene Name: PDCD1
• UniProt Synonym Gene Names: PD1; Protein PD-1; hPD-1
• UniProt Entry Name: PDCD1_HUMAN