IHC (Immunohistochemisry)
(PDCD1/CD279/PD-1 Antibody-Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit PDCD1/CD279/PD-1 Polyclonal Antibody | anti-PDCD1 antibody
PDCD1/CD279/PD-1 Rabbit anti-Human Polyclonal (Internal) Antibody
Gene Names
PDCD1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1
Reactivity
Mouse, Rat, Human
Applications
Western Blot, Immunohistochemistry
Purity
Immunoaffinity purified
Synonyms
PDCD1/CD279/PD-1, Antibody; PDCD1/CD279/PD-1 Rabbit anti-Human Polyclonal (Internal) Antibody; PathPlus PDCD1/CD279/PD-1 Antibody (Internal); PDCD1; CD279; HPD-1; HPD-l; PD1; Protein PD-1; SLEB2; PD-1; CD279 antigen; Programmed cell death 1; anti-PDCD1 antibody
Host
Rabbit
Reactivity
Mouse, Rat, Human
Clonality
Polyclonal
Specificity
Recognizes endogenous levels of CD279 protein.
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, pH7.3, 0.01% Sodium Azide, 30% Glycerol
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-PDCD1 antibody
WB (Western Blot), IHC (Immunohistochemistry)
Target
Human PDCD1/CD279/PD-1
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the central region of human CD279.
Conjugation
Unconjugated
Epitope
Internal
Family
Apoptosis
Preparation and Storage
Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.
IHC (Immunohistochemisry)
(PDCD1/CD279/PD-1 Antibody-Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemisry)
(PDCD1/CD279/PD-1 Antibody-Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(PDCD1/CD279/PD-1 Antibody-Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(PDCD1/CD279/PD-1 Antibody-Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE))
WB (Western Blot)
(PDCD1/CD279/PD-1 Antibody-Western blot analysis of CD279 expression in THP1 (A); HepG2 (B); mouse liver (C); H9C2 (D) whole cell lysates.)
WB (Western Blot)
(PDCD1/CD279/PD-1 Antibody-Western blot analysis of CD279 expression in THP1 (A); HepG2 (B); mouse liver (C); H9C2 (D) whole cell lysates.)
Related Product Information for anti-PDCD1 antibody
PD-1 antibody is an unconjugated rabbit polyclonal antibody to PD-1 (PDCD1/CD279)(Internal) from human. It is reactive with human, mouse and rat. Validated for IHC and WB.
PD1 (Programmed Death Receptor 1, PDCD1, CD279) is an immune checkpoint protein active in T cells that is a target alongside its ligand PDL1 and also CTLA-4 for immunotherapy in lung and other cancers. PD1 is involved in negatively regulating T cell inflammatory activity and, when bound to receptors on tumor cells, can work to subdue tumor suppression by inhibiting the immune response. Targeted inhibition of PD1 itself can therefore function as an anti-cancer therapy by reactivating this response. PD1 is expected to have membranous staining in germinal center associated helper T cells, CD8+ T cells, and Pro-B cells. It is for the identification of subsets of T and B cell lymphomas and nodular lymphocyte predominant Hodgkin lymphomas.
PD1 (Programmed Death Receptor 1, PDCD1, CD279) is an immune checkpoint protein active in T cells that is a target alongside its ligand PDL1 and also CTLA-4 for immunotherapy in lung and other cancers. PD1 is involved in negatively regulating T cell inflammatory activity and, when bound to receptors on tumor cells, can work to subdue tumor suppression by inhibiting the immune response. Targeted inhibition of PD1 itself can therefore function as an anti-cancer therapy by reactivating this response. PD1 is expected to have membranous staining in germinal center associated helper T cells, CD8+ T cells, and Pro-B cells. It is for the identification of subsets of T and B cell lymphomas and nodular lymphocyte predominant Hodgkin lymphomas.
References
Alsaab, 2017; Jin, 2011; Francisco, 2010; Fife, 2011; Human Pathol 2008 39(7):1050
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
31,647 Da
NCBI Official Full Name
programmed cell death protein 1
NCBI Official Synonym Full Names
programmed cell death 1
NCBI Official Symbol
PDCD1
NCBI Official Synonym Symbols
PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1
NCBI Protein Information
programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2
UniProt Protein Name
Programmed cell death protein 1
UniProt Gene Name
PDCD1
UniProt Synonym Gene Names
PD1; Protein PD-1; hPD-1
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Product Notes
The PDCD1 pdcd1 (Catalog #AAA163084) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PDCD1/CD279/PD-1 Rabbit anti-Human Polyclonal (Internal) Antibody reacts with Mouse, Rat, Human and may cross-react with other species as described in the data sheet. AAA Biotech's PDCD1/CD279/PD-1 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the PDCD1 pdcd1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PDCD1/CD279/PD-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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