IHC (Immunohiostchemistry)
(PDE1B Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PDE1B Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit anti-Mouse PDE1B Polyclonal Antibody | anti-PDE1B antibody
PDE1B Antibody (C-term)
Gene Names
PDE1B; PDE1B1; PDES1B; HEL-S-79p
Reactivity
Mouse
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
PDE1B, Antibody; PDE1B Antibody (C-term); Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; Cam-PDE 1B; 63 kDa Cam-PDE; PDE1B; PDE1B1; PDES1B; anti-PDE1B antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This PDE1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 473-500 amino acids from the C-terminal region of human PDE1B.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
473-500
Sequence Length
516
Applicable Applications for anti-PDE1B antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(PDE1B Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PDE1B Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(PDE1B Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PDE1B Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(PDE1B Antibody (C-term) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the PDE1B antibody detected the PDE1B protein (arrow).)
WB (Western Blot)
(PDE1B Antibody (C-term) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the PDE1B antibody detected the PDE1B protein (arrow).)
Related Product Information for anti-PDE1B antibody
Cyclic nucleotide phosphodiesterases (PDEs) catalyze
hydrolysis of the cyclic nucleotides cAMP and cGMP to the
corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs
have been classified into several families based on their
biochemical properties. Members of the PDE1 family, such as PDE1B,
are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are
stimulated by a calcium-calmodulin complex (Repaske et al., 1992
[PubMed 1326532]).
hydrolysis of the cyclic nucleotides cAMP and cGMP to the
corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs
have been classified into several families based on their
biochemical properties. Members of the PDE1 family, such as PDE1B,
are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are
stimulated by a calcium-calmodulin complex (Repaske et al., 1992
[PubMed 1326532]).
Product Categories/Family for anti-PDE1B antibody
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Vandeput, F., et al. J. Biol. Chem. 282(45):32749-32757(2007)
Bender, A.T., et al. Proc. Natl. Acad. Sci. U.S.A. 103(2):460-465(2006)
Bender, A.T., et al. Proc. Natl. Acad. Sci. U.S.A. 102(2):497-502(2005)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Vandeput, F., et al. J. Biol. Chem. 282(45):32749-32757(2007)
Bender, A.T., et al. Proc. Natl. Acad. Sci. U.S.A. 103(2):460-465(2006)
Bender, A.T., et al. Proc. Natl. Acad. Sci. U.S.A. 102(2):497-502(2005)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
61380
NCBI Official Full Name
calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1
NCBI Official Synonym Full Names
phosphodiesterase 1B, calmodulin-dependent
NCBI Official Symbol
PDE1B
NCBI Official Synonym Symbols
PDE1B1; PDES1B; HEL-S-79p
NCBI Protein Information
calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
UniProt Protein Name
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
UniProt Gene Name
PDE1B
UniProt Synonym Gene Names
PDE1B1; PDES1B; Cam-PDE 1B
UniProt Entry Name
PDE1B_HUMAN
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Product Notes
The PDE1B pde1b (Catalog #AAA290255) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 473-500. The PDE1B Antibody (C-term) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's PDE1B can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the PDE1B pde1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PDE1B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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