Rabbit anti-Human, Mouse PDGFRA Polyclonal Antibody | anti-PDGFRA antibody

PDGFRA Antibody

Cat. Num. AAA232620

• Gene Names: PDGFRA; CD140A; PDGFR2; PDGFR-2
• Reactivity: Human, Mouse
• Applications: Immunofluorescence, Western Blot, ELISA
• Purity: >95%, Protein G purified
• Synonyms: PDGFRA, Antibody; PDGFRA Antibody; Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a), PDGFRA,PDGFR2 RHEPDGFRA; anti-PDGFRA antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Applicable Applications for anti-PDGFRA antibody: IF (Immunofluorescence), WB (Western Blot), ELISA
• Immunogen: Recombinant Human Platelet-derived growth factor receptor alpha protein (30-198AA)
• Immunogen Species: Homo sapians (Human)
• Research Area: Cardiovascular
• Target Names: PDGFRA
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-31178 / sc-431 / sc-338
• Preparation and Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

IF (Immunofluorescence)

(Immunofluorescent analysis of U251 cells using AAA232620 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

WB (Western Blot)

(Western BlotPositive WB detected in:HEK293 whole cell lysate, Mouse liver tissueAll lanes: PDGFRA antibody at 3ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 123, 25, 83 kDaObserved band size: 123 kDa)

Related Product Information for anti-PDGFRA antibody

Relevance: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, 4, 5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.

NCBI and Uniprot Product Information

• NCBI GI #: 5453870
• NCBI GeneID: 5156
• NCBI Accession #: NP_006197.1
• NCBI GenBank Nucleotide #: NM_006206.5
• UniProt Accession #: P16234; Q6P4H5; Q96KZ7; Q9UD28; B2RE69; E9PBH0
• NCBI Official Full Name: platelet-derived growth factor receptor alpha isoform 1
• NCBI Official Synonym Full Names: platelet derived growth factor receptor alpha
• NCBI Official Symbol: PDGFRA
• NCBI Official Synonym Symbols: CD140A; PDGFR2; PDGFR-2
• NCBI Protein Information: platelet-derived growth factor receptor alpha
• UniProt Protein Name: Platelet-derived growth factor receptor alpha
• UniProt Gene Name: PDGFRA
• UniProt Synonym Gene Names: PDGFR2; RHEPDGFRA; PDGF-R-alpha; PDGFR-alpha; PDGFR-2
• UniProt Entry Name: PGFRA_HUMAN