WB (Western Blot)
(Figure 1. Western blot analysis of PPARGC1B using anti-PPARGC1B antibody.)
Rabbit anti-Human, Mouse PGC1 beta/PPARGC1B Polyclonal Antibody | anti-PPARGC1B antibody
Anti-PGC1 beta/PPARGC1B Antibody
Gene Names
PPARGC1B; PERC; ERRL1; PGC1B; PGC-1(beta)
Reactivity
Human, Mouse
Applications
ELISA, Flow Cytometry, Functional Assay, Western Blot
Purity
Immunogen affinity purified.
Synonyms
PGC1 beta/PPARGC1B, Antibody; Anti-PGC1 beta/PPARGC1B Antibody; Peroxisome proliferator-activated receptor gamma coactivator 1-beta; PGC-1-beta; PPAR-gamma coactivator 1-beta; PPARGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PPARGC1B; PERC; PGC1; PGC1B; PPARGC1; anti-PPARGC1B antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
No cross reactivity with other proteins.
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Sequence Length
984
Applicable Applications for anti-PPARGC1B antibody
ELISA (Direct ELISA), FCM/FACS (Flow Cytometry), WB (Western Blot)
Immunogen
E Coli-derived human PGC1 beta/PPARGC1B recombinant protein (Position: A8-P375).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.
WB (Western Blot)
(Figure 1. Western blot analysis of PPARGC1B using anti-PPARGC1B antibody.)
WB (Western Blot)
(Figure 1. Western blot analysis of PPARGC1B using anti-PPARGC1B antibody.)
FCM/FACS (Flow Cytometry)
FCM/FACS (Flow Cytometry)
FCM/FACS (Flow Cytometry)
FCM/FACS (Flow Cytometry)
Related Product Information for anti-PPARGC1B antibody
Description: Rabbit IgG polyclonal antibody for PGC1 beta/PPARGC1B detection. Tested with WB, FCM, Direct ELISA in Human;Mouse.
Background: Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene. It is mapped to 5q32. The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene.
Background: Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene. It is mapped to 5q32. The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene.
References
1. Andersen, G., Wegner, L., Yanagisawa, K., Rose, C. S., Glumer, C., Drivsholm, T., Borch-Johnsen, K., Jorgensen, T., Hansen, T., Spiegelman, B. M., Pedersen, O. Evidence of an association between genetic variation of the coactivator PGC-1-beta and obesity. J. Med. Genet. 42: 402-407, 2005.
2. Hentschke, M., Susens, U., Borgmeyer, U. PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma. Biochem. Biophys. Res. Commun. 299: 872-879, 2002.
3. Ishii, K., Fumoto, T., Iwai, K., Takeshita, S., Ito, M., Shimohata, N., Aburatani, H., Taketani, S., Lelliott, C. J., Vidal-Puig, A., Ikeda, K. Coordination of PGC-1-beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nature Med. 15: 259-266, 2009.
2. Hentschke, M., Susens, U., Borgmeyer, U. PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma. Biochem. Biophys. Res. Commun. 299: 872-879, 2002.
3. Ishii, K., Fumoto, T., Iwai, K., Takeshita, S., Ito, M., Shimohata, N., Aburatani, H., Taketani, S., Lelliott, C. J., Vidal-Puig, A., Ikeda, K. Coordination of PGC-1-beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nature Med. 15: 259-266, 2009.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 2
NCBI Official Synonym Full Names
PPARG coactivator 1 beta
NCBI Official Symbol
PPARGC1B
NCBI Official Synonym Symbols
PERC; ERRL1; PGC1B; PGC-1(beta)
NCBI Protein Information
peroxisome proliferator-activated receptor gamma coactivator 1-beta
UniProt Protein Name
Peroxisome proliferator-activated receptor gamma coactivator 1-beta
UniProt Gene Name
PPARGC1B
UniProt Synonym Gene Names
PERC; PGC1; PGC1B; PPARGC1; PGC-1-beta; PPAR-gamma coactivator 1-beta
UniProt Entry Name
PRGC2_HUMAN
Similar Products
Product Notes
The PPARGC1B ppargc1b (Catalog #AAA125458) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-PGC1 beta/PPARGC1B Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's PGC1 beta/PPARGC1B can be used in a range of immunoassay formats including, but not limited to, ELISA (Direct ELISA), FCM/FACS (Flow Cytometry), WB (Western Blot). Researchers should empirically determine the suitability of the PPARGC1B ppargc1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PGC1 beta/PPARGC1B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.