WB (Western Blot)
(Western blot analysis of PKMYT1 using RAW264.7 whole cell lysates)
Rabbit anti-Human, Mouse PKMYT1 Polyclonal Antibody | anti-PKMYT1 antibody
PKMYT1 Antibody
Gene Names
PKMYT1; MYT1; PPP1R126
Reactivity
Human, Mouse
Applications
ELISA, Western Blot
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Synonyms
PKMYT1, Antibody; PKMYT1 Antibody; cdc2 inhibitory kinase; DKFZp547K1610; FLJ20093; Membrane associated tyrosine and threonine specific cdc2 inhibitory kinase; Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase; MYT1; Myt1 kinase; PKMYT 1; Pkmyt1; PMYT1_HUMAN; PPP1R126; Protein kinase membrane associated tyrosine/threonine 1; Protein kinase Myt1; Protein phosphatase 1 regulatory subunit 126; anti-PKMYT1 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
PKMYT1 antibody detects endogenous levels of total PKMYT1
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
430
Applicable Applications for anti-PKMYT1 antibody
ELISA, WB (Western Blot)
Immunogen
A synthesized peptide derived from human Myt1, corresponding to a region within the internal amino acids.
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
WB (Western Blot)
(Western blot analysis of PKMYT1 using RAW264.7 whole cell lysates)
WB (Western Blot)
(Western blot analysis of PKMYT1 using RAW264.7 whole cell lysates)
Related Product Information for anti-PKMYT1 antibody
Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
Subunit Structure: Interacts with CDC2-CCNB1 complex. Can also interact with PIN1 when phosphorylated by CDC2-CCNB1.
Post-translational Modifications: Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity.
Similarity: The membrane-association motif is essential for the localization to membrane of Golgi stack. According to some authors, it is a transmembrane domain; the existence of a transmembrane region is however unproven. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
Subunit Structure: Interacts with CDC2-CCNB1 complex. Can also interact with PIN1 when phosphorylated by CDC2-CCNB1.
Post-translational Modifications: Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity.
Similarity: The membrane-association motif is essential for the localization to membrane of Golgi stack. According to some authors, it is a transmembrane domain; the existence of a transmembrane region is however unproven. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
70kDa
NCBI Official Full Name
membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3
NCBI Official Synonym Full Names
protein kinase, membrane associated tyrosine/threonine 1
NCBI Official Symbol
PKMYT1
NCBI Official Synonym Symbols
MYT1; PPP1R126
NCBI Protein Information
membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
UniProt Protein Name
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
UniProt Gene Name
PKMYT1
UniProt Synonym Gene Names
MYT1
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Product Notes
The PKMYT1 pkmyt1 (Catalog #AAA327403) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PKMYT1 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's PKMYT1 can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the PKMYT1 pkmyt1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PKMYT1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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