IHC (Immunohistochemisry)
(Immunofluorescent analysis of Hela cells using AAA229257 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
Rabbit anti-Human Poly (A)-specific ribonuclease PARN Polyclonal Antibody | anti-PARN antibody
Rabbit anti-human Poly(A)-specific ribonuclease PARN polyclonal Antibody
Gene Names
PARN; DAN; DKCB6; PFBMFT4
Reactivity
Human
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Synonyms
Poly (A)-specific ribonuclease PARN, Antibody; Rabbit anti-human Poly(A)-specific ribonuclease PARN polyclonal Antibody; PAM16 MAGMAS; TIM16; TIMM16 CGI-136; anti-PARN antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation purified
Form/Format
Liquid
Sequence Length
578
Applicable Applications for anti-PARN antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen
Recombinant human Poly(A)-specific ribonuclease PARN protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-47619 / sc-47618 / sc-135242
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
IHC (Immunohistochemisry)
(Immunofluorescent analysis of Hela cells using AAA229257 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
IHC (Immunohistochemisry)
(Immunofluorescent analysis of Hela cells using AAA229257 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embeded human prostate using AAA229257 at dilution of 1:50)
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embeded human prostate using AAA229257 at dilution of 1:50)
WB (Western Blot)
(Western blotAll lanes: Poly(A)-specific ribonuclease PARN antibody at 2ug/mlLane 1:Jurkat whole cell lysateLane 2:A431 whole cell lysateSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 74,67,68,53 kDaObserved band size: 73 kDa)
WB (Western Blot)
(Western blotAll lanes: Poly(A)-specific ribonuclease PARN antibody at 2ug/mlLane 1:Jurkat whole cell lysateLane 2:A431 whole cell lysateSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 74,67,68,53 kDaObserved band size: 73 kDa)
Related Product Information for anti-PARN antibody
3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization.
This protein is a 3 -exoribonuclease, with similarity to the RNase D family of 3 -exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
This protein is a 3 -exoribonuclease, with similarity to the RNase D family of 3 -exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-PARN antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
52,989 Da
NCBI Official Full Name
poly(A)-specific ribonuclease PARN isoform 2
NCBI Official Synonym Full Names
poly(A)-specific ribonuclease
NCBI Official Symbol
PARN
NCBI Official Synonym Symbols
DAN; DKCB6; PFBMFT4
NCBI Protein Information
poly(A)-specific ribonuclease PARN
UniProt Protein Name
Poly(A)-specific ribonuclease PARN
UniProt Gene Name
PARN
UniProt Synonym Gene Names
DAN
UniProt Entry Name
PARN_HUMAN
Similar Products
Product Notes
The PARN parn (Catalog #AAA229257) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Poly(A)-specific ribonuclease PARN polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Poly (A)-specific ribonuclease PARN can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the PARN parn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Poly (A)-specific ribonuclease PARN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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