IF (Immunofluorescence)
(Immunofluorescence of PPM1D in human lung carcinoma tissue with PPM1D antibody at 20 μg/ml.)
Rabbit PPM1D Polyclonal Antibody | anti-PPM1D antibody
PPM1D Antibody
Gene Names
PPM1D; WIP1; PP2C-DELTA
Reactivity
Human, Mouse, Rat
Applications
Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
Purity
PPM1D antibody is affinity chromatography purified via peptide column.
Synonyms
PPM1D, Antibody; PPM1D Antibody; Protein phosphatase Mg2+/Mn2+ dependent 1D; p53-induced protein phosphatase 1; PP2C-DELTA; Protein phosphatase 1D; WIP1 ; anti-PPM1D antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
PPM1D antibody is human, mouse and rat reactive. At least two isoforms of PPM1D are known to exist; this antibody will only detect the larger isoform.
Purity/Purification
PPM1D antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
605
Applicable Applications for anti-PPM1D antibody
IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
Conjugate
Unconjugated
Immunogen
PPM1D antibody was raised against an 18 amino acid peptide near the carboxy terminus of human PPM1D.
Buffer
PPM1D antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
PPM1D antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
IF (Immunofluorescence)
(Immunofluorescence of PPM1D in human lung carcinoma tissue with PPM1D antibody at 20 μg/ml.)
IF (Immunofluorescence)
(Immunofluorescence of PPM1D in human lung carcinoma tissue with PPM1D antibody at 20 μg/ml.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of PPM1D in human lung carcinoma tissue with PPM1D antibody at 5 μg/ml.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of PPM1D in human lung carcinoma tissue with PPM1D antibody at 5 μg/ml.)
WB (Western Blot)
(Western blot analysis of PPM1D in 3T3 cell lysate with PPM1D antibody at 1 μg/ml.)
WB (Western Blot)
(Western blot analysis of PPM1D in 3T3 cell lysate with PPM1D antibody at 1 μg/ml.)
Related Product Information for anti-PPM1D antibody
Wild-type p53 induced phosphatase 1 (WIP1) / protein phosphatase magnesium-dependent 1 delta (PPM1D), a protein identified in the p53 DNA response pathway, is a member of the PP2C family of serine/threonine protein phosphatases which selectively inactivates p38 MAPK and dephosphorylates the ATM/ATR targets, Chk1 and p53 (1,2). Studies have shown that it is overexpressed in human cancers and is involved in the regulation of multiple DNA damage signaling pathways (2,3). PPM1D deletion results in a reduction of T and B cell function and compromised cell division, rendering cells resistant to becoming cancerous and slowing tumor development (4,5).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Predicted: 67 kDa
Observed: 68 kDa
Observed: 68 kDa
NCBI Official Full Name
protein phosphatase 1D
NCBI Official Synonym Full Names
protein phosphatase, Mg2+/Mn2+ dependent, 1D
NCBI Official Symbol
PPM1D
NCBI Official Synonym Symbols
WIP1; PP2C-DELTA
NCBI Protein Information
protein phosphatase 1D; protein phosphatase Wip1; wild-type p53-induced phosphatase 1; protein phosphatase 2C delta isoform; protein phosphatase 1D magnesium-dependent, delta isoform
UniProt Protein Name
Protein phosphatase 1D
UniProt Gene Name
PPM1D
UniProt Synonym Gene Names
WIP1; PP2C-delta
UniProt Entry Name
PPM1D_HUMAN
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Product Notes
The PPM1D ppm1d (Catalog #AAA40793) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PPM1D Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PPM1D can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the PPM1D ppm1d for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PPM1D, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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