Rabbit PRICKLE1 Polyclonal Antibody | anti-PRICKLE1 antibody

PRICKLE1 Antibody

Cat. Num. AAA39237

• Gene Names: PRICKLE1; RILP; EPM1B
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Western Blot, ELISA
• Purity: PRICKLE1 Antibody is affinity chromatography purified via peptide column.
• Synonyms: PRICKLE1, Antibody; PRICKLE1 Antibody; PRICKLE1; RILP; EPM1B; Prickle-like protein 1; prickle homolog 1; anti-PRICKLE1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Multiple isoforms of PRICKLE1 are known to exist. PRICKLE1 antibody is predicted to not cross-react with other PRICKLE protein family members.
• Purity/Purification: PRICKLE1 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 831

• Applicable Applications for anti-PRICKLE1 antibody: IF (Immunofluorescence), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: PRICKLE1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human PRICKLE1.; The immunogen is located within the last 50 amino acids of PRICKLE1.
• Buffer: PRICKLE1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Positive Control: 1) Cat No. - Human Bladder Tissue
• Preparation and Storage: PRICKLE1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of PRICKLE1 in Human Bladder tissue with PRICKLE1 antibody at 20 μg/mL.)

IF (Immunofluorescence)

(Immunofluorescence of PRICKLE1 in human bladder cells with PRICKLE1 antibody at 20 μg/mL.)

WB (Western Blot)

(PRICKLE1 Antibody)

Related Product Information for anti-PRICKLE1 antibody

PRICKLE1 Antibody: PRICKLE1, also known as RILP or EPM1B, is a Disheveled-associated protein that serves as a nuclear translocation receptor for REST/NRSF and REST4 (1, 2). It contains three N-terminal LIM domains and three C-terminal nuclear localization signals. It localizes to the cytoplasm, as well as to the nuclear membrane and expressed at higher levels in placenta. PRICKLE1 is a negative regulator of the Wnt / beta-catenin signaling pathway and is a putative tumor suppressor in human HCCs. Defects in the gene encoding PRICKLE1 are associated with autosomal recessive progressive myoclonic epilepsy.

NCBI and Uniprot Product Information

• NCBI GI #: 222136684
• NCBI GeneID: 144165
• NCBI Accession #: NP_694571
• NCBI GenBank Nucleotide #: NM_001144883.1
• UniProt Accession #: Q96MT3; Q14C83; Q71QF8; Q96N00
• Molecular Weight: Predicted MW: 46.91 kDa; Observed MW: 52.90 kDa
• NCBI Official Full Name: prickle-like protein 1
• NCBI Official Synonym Full Names: prickle homolog 1 (Drosophila)
• NCBI Official Symbol: PRICKLE1
• NCBI Official Synonym Symbols: RILP; EPM1B
• NCBI Protein Information: prickle-like protein 1; prickle-like 1; REST/NRSF-interacting LIM domain protein 1; REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein
• UniProt Protein Name: Prickle-like protein 1
• UniProt Gene Name: PRICKLE1
• UniProt Synonym Gene Names: RILP
• UniProt Entry Name: PRIC1_HUMAN