IHC (Immunohistochemisry)
(PSAP/Prosaposin Antibody-Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Mouse, Human PSAP/Prosaposin Polyclonal Antibody | anti-PSAP antibody
PSAP/Prosaposin Rabbit anti-Human Polyclonal (Internal) Antibody
Gene Names
PSAP; GLBA; SAP1
Reactivity
Mouse, Human
Applications
Western Blot, Immunohistochemistry, Immunohistochemistry
Purity
Immunoaffinity purified
Synonyms
PSAP/Prosaposin, Antibody; PSAP/Prosaposin Rabbit anti-Human Polyclonal (Internal) Antibody; PathPlus PSAP/Prosaposin Antibody (Internal); PSAP; Cerebroside sulfate activator; GLBA; Proactivator polypeptide; Prosaposin; SAP1; anti-PSAP antibody
Host
Rabbit
Reactivity
Mouse, Human
Clonality
Polyclonal
Specificity
Recognizes endogenous levels of Prosaposin protein.
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, pH7.3, 0.01% Sodium Azide, 30% Glycerol
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-PSAP antibody
WB (Western Blot), IHC (Immunohistochemistry), IHC (Immunohistochemistry)
Target
Human PSAP/Prosaposin
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the central region of human Prosaposin.
Conjugation
Unconjugated
Epitope
Internal
Preparation and Storage
Aliquot and store at -20 degree C for 1 year. Avoid freeze/thaw cycles.
IHC (Immunohistochemisry)
(PSAP/Prosaposin Antibody-Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemisry)
(PSAP/Prosaposin Antibody-Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(PSAP/Prosaposin Antibody-Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(PSAP/Prosaposin Antibody-Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE))
WB (Western Blot)
(PSAP/Prosaposin Antibody-Western blot analysis of Prosaposin expression in HepG2 (A); NIH3T3 (B) whole cell lysates.)
WB (Western Blot)
(PSAP/Prosaposin Antibody-Western blot analysis of Prosaposin expression in HepG2 (A); NIH3T3 (B) whole cell lysates.)
Related Product Information for anti-PSAP antibody
Prosaposin antibody is an unconjugated rabbit polyclonal antibody to Prosaposin (PSAP)(Internal) from human. It is reactive with human and mouse. Validated for IHC and WB.
PSAP (Prosaposin, SAP1) is a preproprotein that is proteolytically processed to generate saposins A, B, C, and D. Saposins localize to lysosomes where they catabolize glycosphingolipids with short oligosaccharide groups. The precursor exists as both a secretory and integral membrane protein. The secretory prosaposin promotes protective effects in the nervous system by activating G proteins, including GPR37 and GPR37L1. Mutations in PSAP are associated with Gaucher disease and metachromatic leukodystrophy. The protein is expressed in all tissues.
PSAP (Prosaposin, SAP1) is a preproprotein that is proteolytically processed to generate saposins A, B, C, and D. Saposins localize to lysosomes where they catabolize glycosphingolipids with short oligosaccharide groups. The precursor exists as both a secretory and integral membrane protein. The secretory prosaposin promotes protective effects in the nervous system by activating G proteins, including GPR37 and GPR37L1. Mutations in PSAP are associated with Gaucher disease and metachromatic leukodystrophy. The protein is expressed in all tissues.
References
Brain Res 2014 1585:1; Am J Med Genet 2009 149A(4):613; Mol Genet Metab 2012 106(3):257
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
58,484 Da
NCBI Official Full Name
prosaposin isoform a preproprotein
NCBI Official Synonym Full Names
prosaposin
NCBI Official Symbol
PSAP
NCBI Official Synonym Symbols
GLBA; SAP1
NCBI Protein Information
prosaposin; proactivator polypeptide; sphingolipid activator protein-1
UniProt Protein Name
Proactivator polypeptide
UniProt Gene Name
PSAP
UniProt Synonym Gene Names
GLBA; SAP1; CSAct; SAP-1; SAP-2
UniProt Entry Name
SAP_HUMAN
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Product Notes
The PSAP psap (Catalog #AAA162697) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PSAP/Prosaposin Rabbit anti-Human Polyclonal (Internal) Antibody reacts with Mouse, Human and may cross-react with other species as described in the data sheet. AAA Biotech's PSAP/Prosaposin can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry), IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the PSAP psap for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PSAP/Prosaposin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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