Rabbit PSMA6 Polyclonal Antibody | anti-PSMA6 antibody

PSMA6 Antibody

Cat. Num. AAA305849

• Gene Names: PSMA6; IOTA; p27K; PROS27
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: PSMA6, Antibody; PSMA6 Antibody; IOTA; MGC22756; MGC2333; MGC23846; PROS27; anti-PSMA6 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total PSMA6 protein.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 167

• Applicable Applications for anti-PSMA6 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human PSMA6.
• Target Name: PSMA6
• Preparation and Storage: Store at -20 degree C

IF (Immunofluorescence)

(Immunofluorescence analysis of U2OS cell using PSMA6 antibody. Blue: DAPI for nuclear staining.)

IHC (Immunohistochemisry)

(Immunohistochemical analysis of paraffin-embedded human stomach cancer using PSMA6 antibody at dilution of 1:200 (400x lens).)

IHC (Immunohiostchemistry)

(Immunohistochemical analysis of paraffin-embedded human rectal cancer using PSMA6 antibody at dilution of 1:200 (400x lens).)

WB (Western Blot)

(Western blot analysis of extracts of various cell lines, using PSMA6 antibody.)

Related Product Information for anti-PSMA6 antibody

The 20S proteasome is the major proteolytic enzyme complex involved in intracellular protein degradation. It consists of four stacked rings, each with seven distinct subunits. The two outer layers are identical rings composed of a subunits (called PSMAs), and the two inner layers are identical rings composed of b subunits. While the catalytic sites are located on the b rings (1-3), the a subunits are important for assembly and as binding sites for regulatory proteins (4). Seven different a and ten different b proteasome genes have been identified in mammals (5). PA700, PA28, and PA200 are three major protein complexes that function as activators of the 20S proteasome. PA700 binds polyubiquitin with high affinity and associates with the 20S proteasome to form the 26S proteasome, which preferentially degrades poly-ubiquitinated proteins (1-3). The proteasome has a broad substrate spectrum that includes cell cycle regulators, signaling molecules, tumor suppressors, and transcription factors. By controlling the degradation of these intracellular proteins, the proteasome functions in cell cycle regulation, cancer development, immune responses, protein folding, and disease progression (6-9).

Product Categories/Family for anti-PSMA6 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 532691770
• NCBI GeneID: 5687
• NCBI Accession #: NP_001269161.1
• NCBI GenBank Nucleotide #: NM_001282232.1
• UniProt Accession #: P60900; P34062; Q6IB60; B2R7J9; B4DQR4; B4DXJ9
• Molecular Weight: 18,816 Da
• NCBI Official Full Name: proteasome subunit alpha type-6 isoform b
• NCBI Official Synonym Full Names: proteasome subunit alpha 6
• NCBI Official Symbol: PSMA6
• NCBI Official Synonym Symbols: IOTA; p27K; PROS27
• NCBI Protein Information: proteasome subunit alpha type-6
• UniProt Protein Name: Proteasome subunit alpha type-6
• UniProt Gene Name: PSMA6
• UniProt Synonym Gene Names: PROS27; PROS-27; p27K
• UniProt Entry Name: PSA6_HUMAN