Rabbit PTDSS1 Polyclonal Antibody | anti-PTDSS1 antibody

PTDSS1 Antibody (C-term)

Cat. Num. AAA286049

• Gene Names: PTDSS1; LMHD; PSS1; PSSA
• Reactivity: Human (Predicted Reactivity: Bovine, Hamster, Mouse, Rat)
• Applications: ELISA, Western Blot
• Purity: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Synonyms: PTDSS1, Antibody; PTDSS1 Antibody (C-term); Phosphatidylserine synthase 1; PSS-1; PtdSer synthase 1; Serine-exchange enzyme I; PTDSS1; KIAA0024; PSSA; anti-PTDSS1 antibody

• Host: Rabbit
• Reactivity: Human (Predicted Reactivity: Bovine, Hamster, Mouse, Rat)
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: This PTDSS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 390-418 amino acids from the C-terminal region of human PTDSS1.
• Purity/Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Sequence Positions: 390-418
• Sequence Length: 473

• Applicable Applications for anti-PTDSS1 antibody: ELISA, WB (Western Blot)
• Function: Catalyzes a base-exchange reaction in whichthe polar head group ofphosphatidylethanolamine (PE) orphosphatidylcholine (PC) is replaced byL-serine. In membranes, PTDSS1 catalyzesmainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine.
• Cellular Location: Endoplasmic reticulum membrane; Multi-passmembrane protein Note=Highly enriched in the mitochondria-associated membrane (MAM).
• Preparation and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

WB (Western Blot)

(PTDSS1 Antibody (C-term) (AAA286049) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the PTDSS1 antibody detected the PTDSS1 protein (arrow).)

Related Product Information for anti-PTDSS1 antibody

Phosphatidylserine (PS) accounts for 5 to 10% of cell membrane phospholipids. In addition to its role as a structural component, PS is involved in cell signaling, blood coagulation, and apoptosis. PS is synthesized by a calcium-dependent base-exchange reaction catalyzed by PS synthases (EC 2.7.8.8), like PTDSS1, that exchange L-serine for the polar head group of phosphatidylcholine (PC) or phosphatidylethanolamine (PE) (Sturbois-Balcerzak et al.,2001 [PubMed 11084049]).

Product Categories/Family for anti-PTDSS1 antibody

Signal Transduction

References

Rose, J. Phd, et al. Mol. Med. (2010) In press :
Tomohiro, S., et al. Biochem. J. 418(2):421-429(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Sturbois-Balcerzak, B., et al. J. Biol. Chem. 276(11):8205-8212(2001)
Stone, S.J., et al. J. Biol. Chem. 275(44):34534-34540(2000)

NCBI and Uniprot Product Information

• NCBI GI #: 7662647
• NCBI GeneID: 9791
• NCBI Accession #: NP_055569.1
• NCBI GenBank Nucleotide #: NM_014754.2
• UniProt Accession #: P48651; Q9BUQ5; B4DE85; E5RFC5
• Molecular Weight: 55528
• NCBI Official Full Name: phosphatidylserine synthase 1 isoform 1
• NCBI Official Synonym Full Names: phosphatidylserine synthase 1
• NCBI Official Symbol: PTDSS1
• NCBI Official Synonym Symbols: LMHD; PSS1; PSSA
• NCBI Protein Information: phosphatidylserine synthase 1
• UniProt Protein Name: Phosphatidylserine synthase 1
• UniProt Gene Name: PTDSS1
• UniProt Synonym Gene Names: KIAA0024; PSSA; PSS-1; PtdSer synthase 1
• UniProt Entry Name: PTSS1_HUMAN