IHC (Immunohiostchemistry)
(PTGS2/COX2/COX-2 Antibody-Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Human PTGS2/COX2/COX-2 Polyclonal Antibody | anti-PTGS2 antibody
PTGS2/COX2/COX-2 Rabbit anti-Human Polyclonal Antibody
Gene Names
PTGS2; COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS
Reactivity
Human
Applications
Immunohistochemistry
Purity
Immunoaffinity purified
Synonyms
PTGS2/COX2/COX-2, Antibody; PTGS2/COX2/COX-2 Rabbit anti-Human Polyclonal Antibody; PathPlus PTGS2/COX2/COX-2 Antibody; PTGS2; COX-2; Cyclooxygenase-2; COX2; Cyclooxygenase 2b; HCox-2; GRIPGHS; PGH synthase 2; PGHS-2; PHS II; PHS-2; Prostaglandin H2 synthase 2; PGG/HS; Prostaglandin G/H synthase 2; anti-PTGS2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.1% Sodium Azide
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-PTGS2 antibody
IHC (Immunohistochemistry)
Target
Human PTGS2/COX2/COX-2
Immunogen
LP-10554, synthetic peptide
Conjugation
Unconjugated
Preparation and Storage
Aliquot and store undiluted at -20 degree C or below for up to 1 year. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze-thaw cycles.
IHC (Immunohiostchemistry)
(PTGS2/COX2/COX-2 Antibody-Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(PTGS2/COX2/COX-2 Antibody-Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(PTGS2/COX2/COX-2 Antibody-Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(PTGS2/COX2/COX-2 Antibody-Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))
Related Product Information for anti-PTGS2 antibody
COX-2 antibody is an unconjugated rabbit polyclonal antibody to COX-2 (PTGS2/COX2) from human. Validated for IHC.
Cyclooxygenase 2 (COX-2/PTGS2/ prostaglandin-endoperoxide synthase 2) is an enzyme involved in the conversion of arachidonic acid to prostaglandin H2, a precursor of prostacyclin that is released during inflammation. Unlike COX1, which is constitutively expressed, COX2 is induced upon inflammation. COX2 is a frequent target for inhibitors (coxibs) to treat inflammatory conditions. Aspirin and nonsteroidal anti-inflammatory agents also inhibit prostaglandin and prostacyclin production by COX2. Overexpression of COX2 also occurs in many cancers, and COX2 inhibitors may assist in preventing the development of colorectal cancers. Staining for COX2 is expected to be cytoplasmic and potentially membranous. In normal tissues, it is expressed in a variety of cells including endothelial cells, smooth muscle cells, cardiac myocytes, the brain and spinal cord, kidney, the GI tract, lung and bladder.
Cyclooxygenase 2 (COX-2/PTGS2/ prostaglandin-endoperoxide synthase 2) is an enzyme involved in the conversion of arachidonic acid to prostaglandin H2, a precursor of prostacyclin that is released during inflammation. Unlike COX1, which is constitutively expressed, COX2 is induced upon inflammation. COX2 is a frequent target for inhibitors (coxibs) to treat inflammatory conditions. Aspirin and nonsteroidal anti-inflammatory agents also inhibit prostaglandin and prostacyclin production by COX2. Overexpression of COX2 also occurs in many cancers, and COX2 inhibitors may assist in preventing the development of colorectal cancers. Staining for COX2 is expected to be cytoplasmic and potentially membranous. In normal tissues, it is expressed in a variety of cells including endothelial cells, smooth muscle cells, cardiac myocytes, the brain and spinal cord, kidney, the GI tract, lung and bladder.
References
Biochem Soc Transact 2008 36(3):543; Nat Reviews Drug Discovery 2003 2:179; J Cell Phys 2019 234(5):5683; Gastroenterology 1994 107(4):1183, Curr Med Chem 2000 7(11):1113; PNAS 2016 113(2):434
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
68,996 Da
NCBI Official Full Name
prostaglandin G/H synthase 2
NCBI Official Synonym Full Names
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
NCBI Official Symbol
PTGS2
NCBI Official Synonym Symbols
COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS
NCBI Protein Information
prostaglandin G/H synthase 2; PHS II; PGH synthase 2; cyclooxygenase 2b; prostaglandin H2 synthase 2
UniProt Protein Name
Prostaglandin G/H synthase 2
UniProt Gene Name
PTGS2
UniProt Synonym Gene Names
COX2; COX-2; PGH synthase 2; PGHS-2
UniProt Entry Name
PGH2_HUMAN
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Product Notes
The PTGS2 ptgs2 (Catalog #AAA162958) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PTGS2/COX2/COX-2 Rabbit anti-Human Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PTGS2/COX2/COX-2 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the PTGS2 ptgs2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTGS2/COX2/COX-2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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