IHC (Immunohiostchemistry)
(Immunochemical staining of human RAD9B in human skeletal muscle with rabbit polyclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human RAD9B Polyclonal Antibody | anti-RAD9B antibody
Anti-RAD9B Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
RAD9B, Antibody; Anti-RAD9B Antibody, Rabbit Polyclonal; RAD9B Antibody, Rabbit PAb, Antigen Affinity Purified; anti-RAD9B antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human RAD9B
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-RAD9B antibody
IHC (Immunohistochemistry)
Immunogen
E Coli-derived Human RAD9B fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human RAD9B fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
IHC (Immunohiostchemistry)
(Immunochemical staining of human RAD9B in human skeletal muscle with rabbit polyclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections.)
IHC (Immunohiostchemistry)
(Immunochemical staining of human RAD9B in human skeletal muscle with rabbit polyclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections.)
IHC (Immunohistochemistry)
(Immunochemical staining of human RAD9B in human kidney with rabbit polyclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections.)
IHC (Immunohistochemistry)
(Immunochemical staining of human RAD9B in human kidney with rabbit polyclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-RAD9B antibody
RAD9 is an integral element of the PCNA-like HUS1-RAD1-RAD9 (9-1-1) complex that participates in genotoxin-induced CHK1 activation. RAD9B is a RAD9 paralog in humans and mice. RAD9 and RAD9B share extensive amino acid homology throughout their entire sequences (36% identity in humans, 48% similarity in mice). RAD9B transcripts are highly expressed in human testes, with lower levels found in skeletal muscle. RAD9B is also expressed in tumor cells. Like RAD9, RAD9B associates with HUS1, RAD1, and RAD17, suggesting that it is a RAD9 paralog that engages in similar biochemical reactions. Unlike Rad9, overexpression of Rad9B delays cells in G1 phase. Rad9B migrates to nucleoli after nucleolar stress in an ATR-and JNK-dependent manner, in a newly described nucleolar domain structure containing p21.
References
Perez-Castro AJ, et al. (2012) Rad9b responds to nucleolar stress through atr and jnk signalling, and delays the g1-s transition. J Cell Sci 125 (Pt 5): 1152-1164.Dufault VM, et al. (2003) Identification and characterization of rad9b, a paralog of the rad9 checkpoint gene. Genomics 82 (6): 644-651.Cao X, et al. (2020) Loss of rad9b impairs early neural development and contributes to the risk for human spina bifida. Hum Mutat 41 (4): 786-799.
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Product Notes
The RAD9B (Catalog #AAA256851) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-RAD9B Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RAD9B can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the RAD9B for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RAD9B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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