Rabbit anti-Human S100P Polyclonal Antibody | anti-S100P antibody

Anti-S100P Antibody, Rabbit Polyclonal

Cat. Num. AAA255600

• Gene Names: S100P; MIG9
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Protein A & Antigen Affinity
• Synonyms: S100P, Antibody; Anti-S100P Antibody, Rabbit Polyclonal; S100P Antibody, Rabbit PAb, Antigen Affinity Purified; S100 calcium binding protein P; Anti-MIG9 Antibody; anti-S100P antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human S100P
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-S100P antibody: IHC (Immunohistochemistry), ELISA
• Immunogen: Recombinant Human S100P protein
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with purified, recombinant Human S100P (rh S100P). S100P specific IgG was purified by Human S100P affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

IHC (Immunohiostchemistry)

(Immunochemical staining of human S100P in human placenta with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). The image showing nucleus staining of trophoblastic cells.)

IHC (Immunohistochemistry)

(Immunochemical staining of human S100P in human spleen with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)

Related Product Information for anti-S100P antibody

Protein S100-P, also known as Protein S100-E, S100 calcium-binding protein P, S100P and S100E, is a nucleus and cytoplasm protein that belongs to the S-100 family. S100P/S100E contains twoEF-hand domains. S100P protein regulates calcium signal transduction and mediates cytoskeletal interaction, protein phosphorylation and transcriptional control. S100P/S100E overexpression can upregulate androgen receptor expression and thereby promote prostate cancer progression by increasing cell growth. S100P/S100E may directly confer resistance to chemotherapy. S100P/S100E induction may be considered an important step in the initial stage of lung adenocarcinomas, whereas its downregulation in advanced stages seems to be important for tumour progression in which DNA methylation and/or feedback transcription processes play a critical role. S100P/S100E plays a major role in the aggressiveness of pancreatic cancer that is likely mediated by its ability to activate RAGE. Interference with S100P/S100E may provide a novel approach for treatment of pancreatic cancer. S100P/S100E could be considered a potential drug target or a chemosensitization target, and could also serve as a biomarker for aggressive, hormone-refractory and metastatic prostate cancer.

Product Categories/Family for anti-S100P antibody

Calcium-binding Proteins and Related Molecules

References

Arumugam, T. et al., 2005, Clin Cancer Res. 11 (15): 5356-64. Basu, G.D. et al., 2008, Int J Cancer. 123 (2): 330-9. Rehbein, G. et al., 2008, Int J Mol Med. 22 (1): 69-77. Heil, A. et al., 2011, J Biol Chem. 286 (9): 7227-38.

NCBI and Uniprot Product Information

• NCBI GI #: 119602790
• NCBI GeneID: 6286
• UniProt Accession #: P25815; Q5J7W2
• Molecular Weight: 10,400 Da
• NCBI Official Full Name: S100 calcium binding protein P
• NCBI Official Synonym Full Names: S100 calcium binding protein P
• NCBI Official Symbol: S100P
• NCBI Official Synonym Symbols: MIG9
• NCBI Protein Information: protein S100-P; protein S100-E; S100 calcium-binding protein P; migration-inducing gene 9 protein
• UniProt Protein Name: Protein S100-P
• UniProt Gene Name: S100P
• UniProt Synonym Gene Names: S100E; MIG9
• UniProt Entry Name: S100P_HUMAN