IF (Immunofluorescence)
(Immunofluorescence of phosphoSAMHD1 in human brain tissue with phosphoSAMHD1 antibody at 20 μg/mL.)
Rabbit anti-Human, Mouse SAMHD1 Polyclonal Antibody | anti-SAMHD1 antibody
SAMHD1 (phospho Thr592) Antibody
Gene Names
SAMHD1; DCIP; CHBL2; HDDC1; MOP-5; SBBI88
Reactivity
Human, Mouse
Applications
Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column.
Synonyms
SAMHD1, Antibody; SAMHD1 (phospho Thr592) Antibody; SAM domain and HD domain 1; DCIP; CHBL2; HDDC1; MOP-5; SBBI88; anti-SAMHD1 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
Phospho-SAMHD1 antibody is human and mouse reactive. Phospho-SAMHD1 antibody will only detect the phosphorylated form of SAMHD1.
Purity/Purification
Affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
626
Applicable Applications for anti-SAMHD1 antibody
IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
Conjugate
Unconjugated
Immunogen
Phospho-SAMHD1 antibody was raised against a phosphorylated 18 amino acid peptide near the carboxy terminus of human Phospho-SAMHD1 surrounding T592.
Buffer
SAMHD1 (phospho Thr592) antibody is supplied in PBS containing 0.02% sodium azide.
Species
Human
Preparation and Storage
Store at 4 degree C for three months and -20 degree C, stable for up to one year.
IF (Immunofluorescence)
(Immunofluorescence of phosphoSAMHD1 in human brain tissue with phosphoSAMHD1 antibody at 20 μg/mL.)
IF (Immunofluorescence)
(Immunofluorescence of phosphoSAMHD1 in human brain tissue with phosphoSAMHD1 antibody at 20 μg/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of SAMHD1 (phospho Thr592) in human brain tissue with SAMHD1 (phospho Thr592) antibody at 2.5 μg/ml.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of SAMHD1 (phospho Thr592) in human brain tissue with SAMHD1 (phospho Thr592) antibody at 2.5 μg/ml.)
WB (Western Blot)
(Western blot analysis of SAMHD1 (phospho Thr592) in 293 cells transfected with (A) empty expression vector, (B) wild-type SAMHD1, (C) SAMHD1 (T592A) and (D) SAMHD1 (T592E) with SAMHD1 (phospho Thr592) antibody at 1 μg/ml.)
WB (Western Blot)
(Western blot analysis of SAMHD1 (phospho Thr592) in 293 cells transfected with (A) empty expression vector, (B) wild-type SAMHD1, (C) SAMHD1 (T592A) and (D) SAMHD1 (T592E) with SAMHD1 (phospho Thr592) antibody at 1 μg/ml.)
Related Product Information for anti-SAMHD1 antibody
The SAM domain and HD domain 1 (SAMHD1) protein is upregulated in response to viral infection and is thought to play a role in innate immunity (1). SAMHD1 blocks the infection of HIV-1 and SIVdeltaVpx before reverse transcription in macrophages and dendritic cells (2), and this restriction is regulated by phosphorylation of SAMHD1 (3). Mutations in this gene have been associated with Aicardi-Goutieres syndrome (1).
Product Categories/Family for anti-SAMHD1 antibody
References
1. Rice GI, Bond J, Asipu A, et al. Mutations involved in Aicardi-Goutieres syndrome implicate SAMHD1 as regulator of the innate immune system. Nat. Genet. 2009; 41:829-32. 2. Hrecka K, Hao C, Gierszewska M, et al. Vpx relieves the inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature 2011; 474:654-7. 3. Welbourn S, Dutta SM, Semmes OJ, et al. Restriction of virus infection but not catalytic dNTPase activity is regulated by phosphorylation of SAMHD1. J. Virol. 2013; 87:11516-24.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
69 kDa
NCBI Official Full Name
deoxynucleoside triphosphate triphosphohydrolase SAMHD1
NCBI Official Synonym Full Names
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
NCBI Official Symbol
SAMHD1
NCBI Official Synonym Symbols
DCIP; CHBL2; HDDC1; MOP-5; SBBI88
NCBI Protein Information
deoxynucleoside triphosphate triphosphohydrolase SAMHD1
UniProt Protein Name
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
UniProt Gene Name
SAMHD1
UniProt Synonym Gene Names
MOP5; dNTPase; DCIP; MOP-5
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Product Notes
The SAMHD1 samhd1 (Catalog #AAA40862) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SAMHD1 (phospho Thr592) Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SAMHD1 can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the SAMHD1 samhd1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SAMHD1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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