Rabbit SATB1 Polyclonal Antibody | anti-SATB1 antibody

SATB1 Antibody

Cat. Num. AAA301977

• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Affinity chromatography purified via peptide column
• Synonyms: SATB1, Antibody; SATB1 Antibody; DNA-binding protein SATB1, Special AT-rich sequence-binding protein 1; anti-SATB1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 763

• Applicable Applications for anti-SATB1 antibody: IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 15 amino acid peptide near the carboxy terminus of the human SATB1.
• Target Name: SATB1
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IHC (Immunohiostchemistry)

(Immunohistochemistry of SATB1 in human brain with SATB1 antibody at 5 ug/mL.)

WB (Western Blot)

(Western blot analysis of SATB1 in A20 cell lysate with SATB1 antibody at (A) 2 and (B) 4 ug/mL.)

Related Product Information for anti-SATB1 antibody

Human special AT-rich sequence-binding protein-1 (SATB1) is a nuclear matrix/scaffold-associated region DNA-binding protein, predominantly expressed in the thymus and pre-B cells. Like its homolog SATB2, SATB1 selectively binds double-stranded, special AT-rich DNA sequences in which one strand exclusively consists of well-mixed A, T, and C nucleotides. SATB1 contains a dimerization domain that shares similarity with the PDZ motif, identified as an indispensable element for high-affinity binding of SATB1 to DNA. SATB1 constitutes a functional nuclear architecture that has a 'cage-like' protein distribution surrounding heterochromatin and regulates gene expression through chromatin remodeling/HDAC (histone deacetylase complex) and transcription factors recruitment. SATB1 functions as a 'genome organizer' essential for proper T-cell development. Recent studies show that SATB1 is necessary for breast cancer cells to become metastatic, and when ectopically expressed in non-metastatic cells, can induce invasive activity in vivo. At least two isoforms of SATB1 are known to exist.

Product Categories/Family for anti-SATB1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 196114999
• NCBI GeneID: 6304
• NCBI Accession #: NP_001124482.1
• NCBI GenBank Nucleotide #: NM_001131010.2
• UniProt Accession #: Q01826; Q59EQ0; B3KXF1; C9JTR6
• Molecular Weight: 89,127 Da
• NCBI Official Full Name: DNA-binding protein SATB1 isoform 1
• NCBI Official Synonym Full Names: SATB homeobox 1
• NCBI Official Symbol: SATB1
• NCBI Protein Information: DNA-binding protein SATB1
• UniProt Protein Name: DNA-binding protein SATB1
• UniProt Gene Name: SATB1
• UniProt Entry Name: SATB1_HUMAN