FCM/FACS (Flow Cytometry)
(SCN1B Antibody (N-Term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Rabbit SCN1B Polyclonal Antibody | anti-SCN1B antibody
SCN1B Antibody (N-Term)
Gene Names
SCN1B; ATFB13; BRGDA5; GEFSP1
Reactivity
Human, mouse (Predicted Reactivity: Bovine, Rabbit, Rat)
Applications
Flow Cytometry, Functional Assay, Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
SCN1B, Antibody; SCN1B Antibody (N-Term); Sodium channel subunit beta-1; SCN1B; anti-SCN1B antibody
Host
Rabbit
Reactivity
Human, mouse (Predicted Reactivity: Bovine, Rabbit, Rat)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This SCN1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human SCN1B.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
63-90
Sequence Length
268
Applicable Applications for anti-SCN1B antibody
FCM/FACS (Flow Cytometry), IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
FCM/FACS (Flow Cytometry)
(SCN1B Antibody (N-Term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
FCM/FACS (Flow Cytometry)
(SCN1B Antibody (N-Term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
IHC (Immunohiostchemistry)
(SCN1B Antibody (N-Term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SCN1B Antibody (N-Term) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(SCN1B Antibody (N-Term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SCN1B Antibody (N-Term) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(SCN1B Antibody (N-Term) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the SCN1B antibody detected the SCN1B protein (arrow).)
WB (Western Blot)
(SCN1B Antibody (N-Term) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the SCN1B antibody detected the SCN1B protein (arrow).)
Related Product Information for anti-SCN1B antibody
Voltage-gated sodium channels are heteromeric proteins
that function in the generation and propagation of action
potentials in muscle and neuronal cells. They are composed of one
alpha and two beta subunits, where the alpha subunit provides
channel activity and the beta-1 subunit modulates the kinetics of
channel inactivation. SCN1B encodes a sodium channel beta-1
subunit. Mutations in this gene result in generalized epilepsy with
febrile seizures plus, Brugada syndrome 5, and defects in cardiac
conduction. Multiple transcript variants encoding different
isoforms have been found for this gene.
that function in the generation and propagation of action
potentials in muscle and neuronal cells. They are composed of one
alpha and two beta subunits, where the alpha subunit provides
channel activity and the beta-1 subunit modulates the kinetics of
channel inactivation. SCN1B encodes a sodium channel beta-1
subunit. Mutations in this gene result in generalized epilepsy with
febrile seizures plus, Brugada syndrome 5, and defects in cardiac
conduction. Multiple transcript variants encoding different
isoforms have been found for this gene.
Product Categories/Family for anti-SCN1B antibody
References
Grover, S., et al. Pharmacogenomics 11(7):927-941(2010)
Tan, B.H., et al. Heart Rhythm 7(6):771-778(2010)
Casini, S., et al. Cardiovasc. Res. 85(4):691-700(2010)
Ogawa, R., et al. Int J Clin Pharmacol Ther 48(2):109-119(2010)
Watanabe, H., et al. Circ Arrhythm Electrophysiol 2(3):268-275(2009)
Tan, B.H., et al. Heart Rhythm 7(6):771-778(2010)
Casini, S., et al. Cardiovasc. Res. 85(4):691-700(2010)
Ogawa, R., et al. Int J Clin Pharmacol Ther 48(2):109-119(2010)
Watanabe, H., et al. Circ Arrhythm Electrophysiol 2(3):268-275(2009)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
24707
NCBI Official Full Name
sodium channel subunit beta-1 isoform a
NCBI Official Synonym Full Names
sodium channel, voltage gated, type I beta subunit
NCBI Official Symbol
SCN1B
NCBI Official Synonym Symbols
ATFB13; BRGDA5; GEFSP1
NCBI Protein Information
sodium channel subunit beta-1
UniProt Protein Name
Sodium channel subunit beta-1
UniProt Gene Name
SCN1B
UniProt Entry Name
SCN1B_HUMAN
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Product Notes
The SCN1B scn1b (Catalog #AAA284732) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 63-90. The SCN1B Antibody (N-Term) reacts with Human, mouse (Predicted Reactivity: Bovine, Rabbit, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's SCN1B can be used in a range of immunoassay formats including, but not limited to, FCM/FACS (Flow Cytometry), IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the SCN1B scn1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SCN1B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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