IHC (Immunohiostchemistry)
(Immunohistochemical staining of human brain tissue using Scrapper antibody at 2.5 ug/mL.)
Rabbit SCRAPPER Polyclonal Antibody | anti-SCRAPPER antibody
SCRAPPER Antibody
Gene Names
FBXL20; Fbl2; Fbl20
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
SCRAPPER, Antibody; SCRAPPER Antibody; F-box, Leucine rich repeat protein 20, FBXL20, FBl2, FBL20; anti-SCRAPPER antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
436
Applicable Applications for anti-SCRAPPER antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a 18 amino acid peptide near the amino terminus of the human SCRAPPER.
Target Name
SCRAPPER
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IHC (Immunohiostchemistry)
(Immunohistochemical staining of human brain tissue using Scrapper antibody at 2.5 ug/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemical staining of human brain tissue using Scrapper antibody at 2.5 ug/mL.)
WB (Western Blot)
(Western blot analysis of SCRAPPER in A20 cell lysate with SCRAPPER antibody at (A) 0.5 and (B) 1 ug/mL.)
WB (Western Blot)
(Western blot analysis of SCRAPPER in A20 cell lysate with SCRAPPER antibody at (A) 0.5 and (B) 1 ug/mL.)
Related Product Information for anti-SCRAPPER antibody
Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. Scrapper has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.
Product Categories/Family for anti-SCRAPPER antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
44,980 Da
NCBI Official Full Name
F-box/LRR-repeat protein 20 isoform 1
NCBI Official Synonym Full Names
F-box and leucine-rich repeat protein 20
NCBI Official Symbol
FBXL20
NCBI Official Synonym Symbols
Fbl2; Fbl20
NCBI Protein Information
F-box/LRR-repeat protein 20
UniProt Protein Name
F-box/LRR-repeat protein 20
UniProt Gene Name
FBXL20
UniProt Synonym Gene Names
FBL2
UniProt Entry Name
FXL20_HUMAN
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Product Notes
The SCRAPPER fbxl20 (Catalog #AAA305639) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SCRAPPER Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SCRAPPER can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the SCRAPPER fbxl20 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SCRAPPER, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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