Rabbit anti-Human, Mouse SCUBE3 Polyclonal Antibody | anti-SCUBE3 antibody

SCUBE3 Antibody

Cat. Num. AAA39459

• Gene Names: SCUBE3; CEGF3
• Reactivity: Human, Mouse
• Applications: Immunofluorescence, Western Blot, ELISA
• Purity: SCUBE3 Antibody is affinity chromatography purified via peptide column.
• Synonyms: SCUBE3, Antibody; SCUBE3 Antibody; SCUBE3; CEGF3; Signal peptide; CUB and EGF-like domain-containing protein 3; signal peptide, CUB and EGF-like domain-containing protein 3 precursor; anti-SCUBE3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: At least two isoforms of SCUBE3 are known to exist. SCUBE3 antibody is predicted to not cross-react with other SCUBE members
• Purity/Purification: SCUBE3 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 993

• Applicable Applications for anti-SCUBE3 antibody: IF (Immunofluorescence), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: SCUBE3 antibody was raised against a 15 amino acid synthetic peptide near the center of human SCUBE3.
• Buffer: SCUBE3 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of SCUBE3 in human kidney tissue with SCUBE3 antibody at 20 μg/mL.)

WB (Western Blot)

(Western blot analysis of SCUBE3 in mouse kidney tissue lysate with SCUBE3 antibody at (A) 1 and (B) 2 μg/mL.)

Related Product Information for anti-SCUBE3 antibody

SCUBE3 Antibody: SCUBE3 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and is highly expressed in primary osteoblasts and bones, and to a lesser extent in heart. Other studies have shown that overexpression of SCUBE3 in mice induced cardiac hypertrophy, suggesting that it may also play a role in the regulation of cardiac growth.. SCUBE3 has been shown to be an endogenous TGF-β receptor ligand and is thought to promote lung cancer cell mobility and invasiveness. In lung cancer cells, the secreted SCUBE3 protein was cleaved by MMP2 and MMP9, allowing the activation of the TGF-β receptor, the increase of Smad2/3 transcriptional activity and the upregulation of expression of proteins such as TGF-β1, VEGF, Snail, and Slug.

NCBI and Uniprot Product Information

• NCBI GI #: 31377568
• NCBI GeneID: 222663
• NCBI Accession #: NP_689966
• NCBI GenBank Nucleotide #: NM_152753.3
• UniProt Accession #: Q8IX30; Q5CZB3; Q86UZ9; Q8NAU9; A8K5A3
• Molecular Weight: 109 kDa
• NCBI Official Full Name: signal peptide, CUB and EGF-like domain-containing protein 3 isoform 1
• NCBI Official Synonym Full Names: signal peptide, CUB domain, EGF-like 3
• NCBI Official Symbol: SCUBE3
• NCBI Official Synonym Symbols: CEGF3
• NCBI Protein Information: signal peptide, CUB and EGF-like domain-containing protein 3; CUB domain and EGF-like repeat containing 3; signal peptide, CUB and EGF-like domain containing protein 3; signal peptide-, CUB domain-, and EGF-like domains-containing protein 3
• UniProt Protein Name: Signal peptide, CUB and EGF-like domain-containing protein 3
• UniProt Gene Name: SCUBE3
• UniProt Entry Name: SCUB3_HUMAN