IHC (Immunohiostchemistry)
(SEC63 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SEC63 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit SEC63 Polyclonal Antibody | anti-SEC63 antibody
SEC63 Antibody (N-term)
Gene Names
SEC63; ERdj2; SEC63L; DNAJC23; PRO2507
Reactivity
Human (Predicted Reactivity: Mouse)
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
SEC63, Antibody; SEC63 Antibody (N-term); Translocation protein SEC63 homolog; SEC63; SEC63L; anti-SEC63 antibody
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Mouse)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This SEC63 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 139-168 amino acids from the N-terminal region of human SEC63.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
139-168
Sequence Length
760
Applicable Applications for anti-SEC63 antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(SEC63 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SEC63 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(SEC63 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SEC63 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(SEC63 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the SEC63 antibody detected the SEC63 protein (arrow).)
WB (Western Blot)
(SEC63 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the SEC63 antibody detected the SEC63 protein (arrow).)
Related Product Information for anti-SEC63 antibody
The Sec61 complex is the central component of the protein
translocation apparatus of the endoplasmic reticulum (ER) membrane.
The protein encoded by this gene and SEC62 protein are found to be
associated with ribosome-free SEC61 complex. It is speculated that
Sec61-Sec62-Sec63 may perform post-translational protein
translocation into the ER. The Sec61-Sec62-Sec63 complex might also
perform the backward transport of ER proteins that are subject to
the ubiquitin-proteasome-dependent degradation pathway. The encoded
protein is an integral membrane protein located in the rough ER.
translocation apparatus of the endoplasmic reticulum (ER) membrane.
The protein encoded by this gene and SEC62 protein are found to be
associated with ribosome-free SEC61 complex. It is speculated that
Sec61-Sec62-Sec63 may perform post-translational protein
translocation into the ER. The Sec61-Sec62-Sec63 complex might also
perform the backward transport of ER proteins that are subject to
the ubiquitin-proteasome-dependent degradation pathway. The encoded
protein is an integral membrane protein located in the rough ER.
Product Categories/Family for anti-SEC63 antibody
References
Waanders, E., et al. Clin. Genet. 78(1):47-56(2010)
van Keimpema, L., et al. Liver Int. (2010) In press :
Waanders, E., et al. Histochem. Cell Biol. 129(3):301-310(2008)
You, K.T., et al. PLoS Biol. 5 (5), E109 (2007) :
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
van Keimpema, L., et al. Liver Int. (2010) In press :
Waanders, E., et al. Histochem. Cell Biol. 129(3):301-310(2008)
You, K.T., et al. PLoS Biol. 5 (5), E109 (2007) :
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
87997
NCBI Official Full Name
translocation protein SEC63 homolog
NCBI Official Synonym Full Names
SEC63 homolog (S. cerevisiae)
NCBI Official Symbol
SEC63
NCBI Official Synonym Symbols
ERdj2; SEC63L; DNAJC23; PRO2507
NCBI Protein Information
translocation protein SEC63 homolog
UniProt Protein Name
Translocation protein SEC63 homolog
UniProt Gene Name
SEC63
UniProt Synonym Gene Names
SEC63L
UniProt Entry Name
SEC63_HUMAN
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Product Notes
The SEC63 sec63 (Catalog #AAA288842) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 139-168. The SEC63 Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's SEC63 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the SEC63 sec63 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SEC63, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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