Rabbit SHH Polyclonal Antibody | anti-SHH antibody

SHH Polyclonal Antibody

Cat. Num. AAA166751

• Gene Names: SHH; TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen affinity purification
• Synonyms: SHH, Antibody; SHH Polyclonal Antibody; TPT, HHG1, HLP3, HPE3, SMMCI, TPTPS, MCOPCB5; anti-SHH antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2.4mg/mL (varies by lot)
• Sequence Length: 462

• Applicable Applications for anti-SHH antibody: IHC (Immunohistochemistry), ELISA
• Immunogen: Synthetic peptide of human SHH
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

IHC (Immunohiostchemistry)

(Immunohistochemistry of paraffin-embedded Human colon cancer tissue using SHH Polyclonal Antibody at dilution 1:70)

IHC (Immunohistochemistry)

(Immunohistochemistry of paraffin-embedded Human breast cancer tissue using SHH Polyclonal Antibody at dilution 1:70)

Related Product Information for anti-SHH antibody

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.

Product Categories/Family for anti-SHH antibody

Stem cells; Cancer; Epigenetics

NCBI and Uniprot Product Information

• NCBI GI #: 6094283
• NCBI GeneID: 6469
• Molecular Weight: 49,607 Da
• NCBI Official Full Name: Sonic hedgehog protein
• NCBI Official Synonym Full Names: sonic hedgehog
• NCBI Official Symbol: SHH
• NCBI Official Synonym Symbols: TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5
• NCBI Protein Information: sonic hedgehog protein; sonic hedgehog homolog
• UniProt Protein Name: Sonic hedgehog protein
• UniProt Gene Name: SHH
• UniProt Synonym Gene Names: SHH
• UniProt Entry Name: SHH_HUMAN