IHC (Immunohiostchemistry)
(Immunohistochemistry of SHOC2 in human spleen tissue with SHOC2 antibody at 5 ug/mL.)
Rabbit SHOC2 Polyclonal Antibody | anti-SHOC2 antibody
SHOC2 Antibody
Gene Names
SHOC2; SOC2; SUR8; SIAA0862
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
SHOC2, Antibody; SHOC2 Antibody; Leucine-rich repeat protein SHOC-2, Ras-binding protein Sur-8, SOC2; anti-SHOC2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
582
Applicable Applications for anti-SHOC2 antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a 21 amino acid peptide near the amino terminus of human SHOC2.
Target Name
SHOC2
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IHC (Immunohiostchemistry)
(Immunohistochemistry of SHOC2 in human spleen tissue with SHOC2 antibody at 5 ug/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of SHOC2 in human spleen tissue with SHOC2 antibody at 5 ug/mL.)
WB (Western Blot)
(Western blot analysis of SHOC2 in Jurkat cell lysate with SHOC2 antibody at (A) 1 and (B) 2 ug/mL.)
WB (Western Blot)
(Western blot analysis of SHOC2 in Jurkat cell lysate with SHOC2 antibody at (A) 1 and (B) 2 ug/mL.)
Related Product Information for anti-SHOC2 antibody
SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.
Product Categories/Family for anti-SHOC2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
59,743 Da
NCBI Official Full Name
leucine-rich repeat protein SHOC-2 isoform 1
NCBI Official Synonym Full Names
SHOC2 leucine-rich repeat scaffold protein
NCBI Official Symbol
SHOC2
NCBI Official Synonym Symbols
SOC2; SUR8; SIAA0862
NCBI Protein Information
leucine-rich repeat protein SHOC-2
UniProt Protein Name
Leucine-rich repeat protein SHOC-2
UniProt Gene Name
SHOC2
UniProt Synonym Gene Names
KIAA0862
UniProt Entry Name
SHOC2_HUMAN
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Product Notes
The SHOC2 shoc2 (Catalog #AAA303904) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SHOC2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SHOC2 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the SHOC2 shoc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SHOC2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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