Rabbit anti-Human, Mouse SIGIRR Polyclonal Antibody | anti-SIGIRR antibody

SIGIRR Antibody

Cat. Num. AAA39713

• Gene Names: SIGIRR; TIR8
• Reactivity: Human, Mouse
• Applications: Immunocytochemistry, Western Blot, ELISA
• Purity: SIGIRR Antibody is affinity chromatography purified via peptide column.
• Synonyms: SIGIRR, Antibody; SIGIRR Antibody; SIGIRR Antibody: TIR8, Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, TIR8; anti-SIGIRR antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: SIGIRR Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid; SIGIRR Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 410

• Applicable Applications for anti-SIGIRR antibody: ICC (Immunocytochemistry), WB (Western Blot), ELISA
• Immunogen: SIGIRR antibody was raised against a synthetic peptide corresponding to 15 amino acids at the C-terminus of human SIGIRR. The immunogen is located within the last 50 amino acids of SIGIRR.
• Homology: Predicted species reactivity based on immunogen sequence: Rat: (100%)
• Conjugate: Unconjugated
• Positive Control: MBS151733 - MCF Cell Lysate; MBS154287 - A549 Cell Slide
• Preparation and Storage: SIGIRR antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ICC (Immunocytochemistry)

(Immunocytochemistry of SIGIRR in A549 cells with SIGIRR antibody at 10 μg/mL.)

WB (Western Blot)

(Western blot analysis of SIGIRR expression in (A) A549 and (B) MCF7 cell lysate with SIGIRR antibody at  1 μg/ml.)

Related Product Information for anti-SIGIRR antibody

SIGIRR Antibody: SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family. Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling. However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion.

NCBI and Uniprot Product Information

• NCBI GI #: 48146793
• NCBI GeneID: 59307
• UniProt Accession #: Q6IA17; Q3KQY2; Q6UXI3; Q9H733
• Molecular Weight: Predicted MW: 45 kDa; Observed MW: 45 kDa
• NCBI Official Full Name: SIGIRR
• NCBI Official Synonym Full Names: single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
• NCBI Official Symbol: SIGIRR
• NCBI Official Synonym Symbols: TIR8
• NCBI Protein Information: single Ig IL-1-related receptor; toll/interleukin-1 receptor 8; single Ig IL-1R-related molecule; single immunoglobulin domain IL1R1 related; single immunoglobulin domain-containing IL1R-related protein
• UniProt Protein Name: Single Ig IL-1-related receptor
• UniProt Gene Name: SIGIRR
• UniProt Synonym Gene Names: TIR8
• UniProt Entry Name: SIGIR_HUMAN