ICC (Immunocytochemistry)
(Immunocytochemistry of SIP1 in HeLa cells with SIP1 antibody at 4 ug/mL.)
Rabbit SIP1 Polyclonal Antibody | anti-SIP1 antibody
SIP1 Antibody
Gene Names
GEMIN2; SIP1; SIP1-delta
Reactivity
Human, Mouse, Rat
Applications
Immunocytochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
SIP1, Antibody; SIP1 Antibody; Survival of motor neuron protein-interacting protein 1, GEMIN2; anti-SIP1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
280
Applicable Applications for anti-SIP1 antibody
ICC (Immunocytochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a 19 amino acid peptide near the carboxy terminus of human SIP1.
Target Name
SIP1
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
ICC (Immunocytochemistry)
(Immunocytochemistry of SIP1 in HeLa cells with SIP1 antibody at 4 ug/mL.)
ICC (Immunocytochemistry)
(Immunocytochemistry of SIP1 in HeLa cells with SIP1 antibody at 4 ug/mL.)
WB (Western Blot)
(Western blot analysis of SIP1 in HeLa cell lysate with SIP1 antibody at (A) 0.5 and (B) 1ug/mL.)
WB (Western Blot)
(Western blot analysis of SIP1 in HeLa cell lysate with SIP1 antibody at (A) 0.5 and (B) 1ug/mL.)
Related Product Information for anti-SIP1 antibody
SIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. SIP1 interacts directly with the SMN and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. However, knockdown of the SIP1 mRNA in motor neurons showed normal motor axons while that of SMN mRNA did show abnormal motor axon outgrowth, indicating that SIP1 may have additional roles outside of the SMN complex.
Product Categories/Family for anti-SIP1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
4,826 Da
NCBI Official Full Name
survival of motor neuron protein interacting protein 1
NCBI Official Synonym Full Names
gem (nuclear organelle) associated protein 2
NCBI Official Symbol
GEMIN2
NCBI Official Synonym Symbols
SIP1; SIP1-delta
NCBI Protein Information
gem-associated protein 2
UniProt Protein Name
Gem-associated protein 2
UniProt Gene Name
GEMIN2
UniProt Synonym Gene Names
SIP1; Gemin-2; SMN-interacting protein 1
UniProt Entry Name
GEMI2_HUMAN
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Product Notes
The SIP1 gemin2 (Catalog #AAA304510) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SIP1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SIP1 can be used in a range of immunoassay formats including, but not limited to, ICC (Immunocytochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the SIP1 gemin2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SIP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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