WB (Western Blot)
(Western blot analysis of extracts from colo cells (Lane 2), using Sirp a1 antiobdy. The lane on the left is treated with synthesized peptide.)
Rabbit Sirp alpha1 Polyclonal Antibody | anti-Sirp alpha1 antibody
Sirp alpha1 Antibody
Gene Names
SIRPA; BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
Sirp alpha1, Antibody; Sirp alpha1 Antibody; Sirp a1 Antibody; Bit; MFR; MYD-1 antigen; MYD1; Macrophage fusion receptor; anti-Sirp alpha1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total Sirp a1 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
504
Applicable Applications for anti-Sirp alpha1 antibody
IHC (Immunohistochemistry), WB (Western Blot)
Immunogen Type
Peptide
Immunogen Description
Synthesized peptide derived from human SIRP-alpha1.
Target Name
Sirp a1
Preparation and Storage
Store at -20 degree C
WB (Western Blot)
(Western blot analysis of extracts from colo cells (Lane 2), using Sirp a1 antiobdy. The lane on the left is treated with synthesized peptide.)
WB (Western Blot)
(Western blot analysis of extracts from colo cells (Lane 2), using Sirp a1 antiobdy. The lane on the left is treated with synthesized peptide.)
WB (Western Blot)
(Western blot analysis of extracts from HepG2 cells, using Sirp a1 antibody.)
WB (Western Blot)
(Western blot analysis of extracts from HepG2 cells, using Sirp a1 antibody.)
IHC (Immunohistochemistry)
(Immunohistochemical analysis of paraffin-embedded human brain tissue using Sirp a1 antibody.)
IHC (Immunohistochemistry)
(Immunohistochemical analysis of paraffin-embedded human brain tissue using Sirp a1 antibody.)
Related Product Information for anti-Sirp alpha1 antibody
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.Kentaro Ide, PNAS, Mar 2007; 104: 5062 - 5066. Thomas T. Chen, Cancer Res., Jan 2004; 64: 117 - 127. Shu Q. Liu, J. Biol. Chem., Nov 2005; 280: 39294 - 39301. Gurpreet S. Kapoor, Cancer Res., Sep 2004; 64: 6444 - 6452.
Product Categories/Family for anti-Sirp alpha1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
54,852 Da
NCBI Official Full Name
tyrosine-protein phosphatase non-receptor type substrate 1
NCBI Official Synonym Full Names
signal-regulatory protein alpha
NCBI Official Symbol
SIRPA
NCBI Official Synonym Symbols
BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1
NCBI Protein Information
tyrosine-protein phosphatase non-receptor type substrate 1
UniProt Protein Name
Tyrosine-protein phosphatase non-receptor type substrate 1
UniProt Gene Name
SIRPA
UniProt Synonym Gene Names
BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP; SHP substrate 1; SHPS-1; Bit; Sirp-alpha-1; Sirp-alpha-2; Sirp-alpha-3
UniProt Entry Name
SHPS1_HUMAN
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Product Notes
The Sirp alpha1 sirpa (Catalog #AAA303008) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Sirp alpha1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Sirp alpha1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the Sirp alpha1 sirpa for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Sirp alpha1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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