IHC (Immunohistochemisry)
(Anti- SIRT6Picoband antibody, AAA46252, IHC(P)IHC(P): Human Mammary Cancer Tissue)
anti-Human, Mouse SIRT6 Polyclonal Antibody | anti-SIRT6 antibody
Anti-SIRT6 Antibody
Gene Names
SIRT6; SIR2L6
Reactivity
Human, Mouse
Applications
Immunohistochemistry, Western Blot
Purity
Immunogen Affinity Purified
Synonyms
SIRT6, Antibody; Anti-SIRT6 Antibody; NAD-dependent protein deacetylase sirtuin-6; 2810449N18Rik; AI043036; Mono ADP ribosyltransferase sirtuin 6; Mono-ADP-ribosyltransferase sirtuin-6; NAD-dependent deacetylase sirtuin-6; Regulatory proteinSIR2 homolog; SIR2 like 6; SIR2 like protein 6; Sir2 related protein type 6; SIR2-like protein 6; SIR2L6; SIRT 6; SIRT6; SIRT6_HUMAN; Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); Sirtuin 6; Sirtuin type 6; Sirtuin6; sirtuin 6; anti-SIRT6 antibody
Reactivity
Human, Mouse
Clonality
Polyclonal
Purity/Purification
Immunogen Affinity Purified
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Sequence Length
328
Applicable Applications for anti-SIRT6 antibody
IHC (Immunohistochemistry), WB (Western Blot)
Immunogen
E Coli-derived human SIRT6 recombinant protein (Position: D14-E180). Human SIRT6 shares 95% amino acid (aa) sequence identity with mouse SIRT6.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
IHC (Immunohistochemisry)
(Anti- SIRT6Picoband antibody, AAA46252, IHC(P)IHC(P): Human Mammary Cancer Tissue)
IHC (Immunohistochemisry)
(Anti- SIRT6Picoband antibody, AAA46252, IHC(P)IHC(P): Human Mammary Cancer Tissue)
IHC (Immunohiostchemistry)
(Anti- SIRT6Picoband antibody, AAA46252, IHC(P)IHC(P): Mouse Cardiac Muscle Tissue)
IHC (Immunohiostchemistry)
(Anti- SIRT6Picoband antibody, AAA46252, IHC(P)IHC(P): Mouse Cardiac Muscle Tissue)
WB (Western Blot)
(Anti- SIRT6Picoband antibody, AAA46252, Western blottingAll lanes: Anti SIRT6 (AAA46252) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: A549 Whole Cell Lysate at 40ugLane 3: Human Placenta Tissue Lysate at 50ugPredicted bind size: 39KDObserved bind size: 39KD)
WB (Western Blot)
(Anti- SIRT6Picoband antibody, AAA46252, Western blottingAll lanes: Anti SIRT6 (AAA46252) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: A549 Whole Cell Lysate at 40ugLane 3: Human Placenta Tissue Lysate at 50ugPredicted bind size: 39KDObserved bind size: 39KD)
Related Product Information for anti-SIRT6 antibody
Description: Rabbit IgG polyclonal antibody for NAD-dependent protein deacetylase sirtuin-6(SIRT6) detection. Tested with WB, IHC-P in Human;Mouse.
Background: SIRT6 is also known as SIR2L6. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.
Background: SIRT6 is also known as SIR2L6. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.
References
1. Kugel S, et al. Chromatin and beyond: the multitasking roles for SIRT6. Trends Biochem Sci, 2014 Feb. 2. Takasaka N, et al. Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence. J Immunol, 2014 Feb 1. 3. Zhang ZG, et al. Sirt6 suppresses hepatocellular carcinoma cell growth via inhibiting the extracellular signal regulated kinase signaling pathway. Mol Med Rep, 2014 Mar.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
36,065 Da
NCBI Official Full Name
NAD-dependent protein deacetylase sirtuin-6 isoform 2
NCBI Official Synonym Full Names
sirtuin 6
NCBI Official Symbol
SIRT6
NCBI Official Synonym Symbols
SIR2L6
NCBI Protein Information
NAD-dependent protein deacetylase sirtuin-6
UniProt Protein Name
NAD-dependent protein deacetylase sirtuin-6
UniProt Gene Name
SIRT6
UniProt Synonym Gene Names
SIR2L6
UniProt Entry Name
SIR6_HUMAN
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Product Notes
The SIRT6 sirt6 (Catalog #AAA46252) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-SIRT6 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SIRT6 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the SIRT6 sirt6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SIRT6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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