FCM/FACS (Flow Cytometry)
(SLC39A10 Antibody (Center) flow cytometric analysis of WiDr cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Rabbit anti-Human SLC39A10 Polyclonal Antibody | anti-SLC39A10 antibody
SLC39A10 Antibody (Center)
Gene Names
SLC39A10; LZT-Hs2
Reactivity
Human
Applications
ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry, Western Blot
Purity
This antibody is purified through a protein A column, followed by peptide affinity purification.
Synonyms
SLC39A10, Antibody; SLC39A10 Antibody (Center); Zinc transporter ZIP10; Solute carrier family 39 member 10; Zrt- and Irt-like protein 10; ZIP-10; SLC39A10; KIAA1265; ZIP10; anti-SLC39A10 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
This SLC39A10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-317 amino acids from the Central region of human SLC39A10.
Purity/Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Applicable Applications for anti-SLC39A10 antibody
ELISA, FCM/FACS (Flow Cytometry), IHC (Immunohistochemistry), WB (Western Blot)
Function
Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity).
Cellular Location
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Expressed at the apical membranes of proximal tubules in the kidney.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
FCM/FACS (Flow Cytometry)
(SLC39A10 Antibody (Center) flow cytometric analysis of WiDr cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
FCM/FACS (Flow Cytometry)
(SLC39A10 Antibody (Center) flow cytometric analysis of WiDr cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
IHC (Immunohiostchemistry)
(SLC39A10 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SLC39A10 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(SLC39A10 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SLC39A10 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(SLC39A10 Antibody (Center) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the SLC39A10 antibody detected the SLC39A10 protein (arrow).)
WB (Western Blot)
(SLC39A10 Antibody (Center) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the SLC39A10 antibody detected the SLC39A10 protein (arrow).)
Related Product Information for anti-SLC39A10 antibody
Zinc is an essential cofactor for hundreds of enzymes. Itis involved in protein, nucleic acid, carbohydrate, and lipidmetabolism, as well as in the control of gene transcription,growth, development, and differentiation. SLC39A10 belongs to asubfamily of proteins that show structural characteristics of zinctransporters (Taylor and Nicholson, 2003 [PubMed12659941]).
Product Categories/Family for anti-SLC39A10 antibody
References
Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008)Taylor, K.M., et al. Biochim. Biophys. Acta 1611 (1-2), 16-30 (2003)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
zinc transporter ZIP10
NCBI Official Synonym Full Names
solute carrier family 39 (zinc transporter), member 10
NCBI Official Symbol
SLC39A10
NCBI Official Synonym Symbols
LZT-Hs2
NCBI Protein Information
zinc transporter ZIP10; ZIP-10; zrt- and Irt-like protein 10; solute carrier family 39 member 10; solute carrier family 39 (metal ion transporter), member 10
UniProt Protein Name
Zinc transporter ZIP10
UniProt Gene Name
SLC39A10
UniProt Synonym Gene Names
KIAA1265; ZIP10; ZIP-10
UniProt Entry Name
S39AA_HUMAN
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Product Notes
The SLC39A10 slc39a10 (Catalog #AAA296709) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SLC39A10 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SLC39A10 can be used in a range of immunoassay formats including, but not limited to, ELISA, FCM/FACS (Flow Cytometry), IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the SLC39A10 slc39a10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC39A10, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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