Rabbit anti-Human SLC39A14 Polyclonal Antibody | anti-SLC39A14 antibody

SLC39A14 Antibody (N-term)

Cat. Num. AAA289830

• Gene Names: SLC39A14; NET34; ZIP14; cig19; LZT-Hs4
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: SLC39A14, Antibody; SLC39A14 Antibody (N-term); Zinc transporter ZIP14; LIV-1 subfamily of ZIP zinc transporter 4; LZT-Hs4; Solute carrier family 39 member 14; Zrt- and Irt-like protein 14; ZIP-14; SLC39A14; KIAA0062; ZIP14; anti-SLC39A14 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: This SLC39A14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-58 amino acids from the N-terminal region of human SLC39A14.
• Purity/Purification: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Positions: 29-58
• Sequence Length: 492

• Applicable Applications for anti-SLC39A14 antibody: ELISA, WB (Western Blot)
• Function: Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis,metabolism, development and immunity (PubMed:15642354, PubMed:27231142, PubMed:29621230). Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions (By similarity). Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic (By similarity). Controls the cellular uptake by the intestinal epithelium of systemic zinc, which is in turn required to maintain tight junctions and the intestinal permeability (By similarity). Modifies the activity of zinc-dependent phosphodiesterases, thereby indirectly regulating G protein-coupled receptor signaling pathways important for gluconeogenesis and chondrocyte differentiation (By similarity). Regulates insulin receptor signaling, glucose uptake, glycogen synthesis and gluconeogenesis in hepatocytes through the zinc-dependent intracellular catabolism of insulin (PubMed:27703010). Through zinc cellular uptake also plays a role in the adaptation of cells to endoplasmic reticulum stress (By similarity). Major manganese transporter of the basolateral membrane of intestinal epithelial cells, it plays a central role in manganese systemic homeostasis through intestinal manganese uptake (PubMed:31028174). Also involved in manganese extracellular uptake by cells of the blood-brain barrier (PubMed:31699897). May also play a role in manganese and zinc homeostasis participating in their elimination from the blood through the hepatobiliary excretion (By similarity). Also functions in the extracellular uptake of free iron. May also function intracellularly and mediate the transport from endosomes to cytosol of iron endocytosed by transferrin (PubMed:20682781). Plays a role in innate immunity by regulating the expression of cytokines by activated macrophages (PubMed:23052185).
• Preparation and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

WB (Western Blot)

(All lanes : Anti-SLC39A14 Antibody (N-term) at 1:2000 dilutionLane 1: U-251 MG whole cell lysateLane 2: Hela whole cell lysateLane 3: 293 whole cell lysateLane 4: Jurkat whole cell lysateLane 5: HepG2 whole cell lysateLane 6: Human liver lysate Lysates/proteins at 20 ug per lane.Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 54 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-SLC39A14 antibody

Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A14 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).

Product Categories/Family for anti-SLC39A14 antibody

Metabolism; Signal Transduction

References

Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)
Gao, J., et al. J. Biol. Chem. 283(31):21462-21468(2008)
Liuzzi, J.P., et al. Proc. Natl. Acad. Sci. U.S.A. 102(19):6843-6848(2005)
Taylor, K.M., et al. FEBS Lett. 579(2):427-432(2005)
Taylor, K.M., et al. Biochim. Biophys. Acta 1611 (1-2), 16-30 (2003) :

NCBI and Uniprot Product Information

• NCBI GI #: 190360568
• NCBI GeneID: 23516
• NCBI Accession #: NP_001121903.1; NP_001128625.1; NP_001128626.1; NP_056174.2
• NCBI GenBank Nucleotide #: NM_001128431.2
• UniProt Accession #: Q15043; Q6ZME8; Q96BB3; A6NH98; B4DIW3; B6EU88; D3DSR4
• NCBI Official Full Name: zinc transporter ZIP14 isoform a
• NCBI Official Synonym Full Names: solute carrier family 39 (zinc transporter), member 14
• NCBI Official Symbol: SLC39A14
• NCBI Official Synonym Symbols: NET34; ZIP14; cig19; LZT-Hs4
• NCBI Protein Information: zinc transporter ZIP14
• UniProt Protein Name: Zinc transporter ZIP14
• UniProt Gene Name: SLC39A14
• UniProt Synonym Gene Names: KIAA0062; ZIP14; LZT-Hs4; ZIP-14
• UniProt Entry Name: S39AE_HUMAN